Alterations to multisensory and unisensory integration by stimulus competition

• Published in: Journal of neurophysiology Vol. 106; no. 6; pp. 3091 - 3101
• Main Authors: Pluta, Scott R, Rowland, Benjamin A, Stanford, Terrence R, Stein, Barry E
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.12.2011
• Subjects: Acoustic Stimulation; Action Potentials - physiology; Animals; Auditory Perception - physiology; Cats; Models, Biological; Neural Inhibition - physiology; Neurons - physiology; Photic Stimulation; Psychophysics; Superior Colliculi - cytology; Superior Colliculi - physiology; Visual Perception - physiology
• ISSN: 0022-3077; 1522-1598
• DOI: 10.1152/jn.00509.2011

In environments containing sensory events at competing locations, selecting a target for orienting requires prioritization of stimulus values. Although the superior colliculus (SC) is causally linked to the stimulus selection process, the manner in which SC multisensory integration operates in a competitive stimulus environment is unknown. Here we examined how the activity of visual-auditory SC neurons is affected by placement of a competing target in the opposite hemifield, a stimulus configuration that would, in principle, promote interhemispheric competition for access to downstream motor circuitry. Competitive interactions between the targets were evident in how they altered unisensory and multisensory responses of individual neurons. Responses elicited by a cross-modal stimulus (multisensory responses) proved to be substantially more resistant to competitor-induced depression than were unisensory responses (evoked by the component modality-specific stimuli). Similarly, when a cross-modal stimulus served as the competitor, it exerted considerably more depression than did its individual component stimuli, in some cases producing more depression than predicted by their linear sum. These findings suggest that multisensory integration can help resolve competition among multiple targets by enhancing orientation to the location of cross-modal events while simultaneously suppressing orientation to events at alternate locations.