Relation of stent design and stent surface material to subsequent in-stent intimal hyperplasia in coronary arteries determined by intravascular ultrasound

• Published in: The American journal of cardiology Vol. 89; no. 12; pp. 1360 - 1364
• Main Authors: Hoffmann, Rainer, Mintz, Gary S, Haager, Philipp K, Bozoglu, Togul, Grube, Eberhard, Gross, Michael, Beythien, Christian, Mudra, Harald, vom Dahl, Jürgen, Hanrath, Peter
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 15.06.2002; Elsevier; Elsevier Limited
• Subjects: Analysis of Variance; Biological and medical sciences; Chi-Square Distribution; Coronary Angiography; Coronary Artery Disease - diagnostic imaging; Coronary Artery Disease - pathology; Coronary Artery Disease - therapy; Coronary vessels; Coronary Vessels - diagnostic imaging; Coronary Vessels - pathology; Diseases of the cardiovascular system; Endosonography; Equipment Design; Female; Gold - adverse effects; Humans; Hyperplasia - diagnostic imaging; Male; Medical sciences; Middle Aged; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Recurrence; Risk Factors; Stents; Stents - adverse effects; Tunica Intima - pathology; Ultrasonic imaging; Sonography; Human; Endoprosthesis; Gold; Echocardiography; Prognosis; Coronary artery; Instrumentation therapy; Endovascular route; Instrumental dilatation; Steel; Coated material; Restenosis; Treatment; Technique; Comparative study
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/S0002-9149(02)02347-0

A variety of different stent designs and coatings have become available. This study sought to determine the impact of stent design and gold-coating of stents on intimal hyperplasia (IH) in human atherosclerotic coronary arteries in relation to known predictors of restenosis. Angiographic and intravascular ultrasound (IVUS) studies were performed at 6-month follow-up on 311 native coronary lesions of 311 patients treated with 99 Multi-Link stents, 74 InFlow steel stents, 73 InFlow gold-coated stents, 41 Palmaz-Schatz stents, 12 NIR steel stents, and 12 gold-coated NIR Royal stents. Lumen and stent cross-sectional area (CSA) were measured at 1-mm axial increments. Mean IH CSA (stent CSA − lumen CSA) and mean IH thickness were calculated and averaged over the total stent length. IVUS demonstrated different levels of IH for the 6 stents. Mean IH thickness ranged from 0.20 ± 0.13 mm for Multi-Link stents to 0.43 ± 0.14 mm for InFlow goal-coated stents (p <0.001). Multivariate analysis proved non–Multi-Link stent design (odds ratio 3.45, 95% confidence intervals 1.13 to 11.11, p <0.034) and gold coating (odds ratio 3.78, 95% confidence intervals 1.88 to 7.54, p <0.001) to be the only independent predictors of IH thickness >0.3 mm. In conclusion, stent design and surface material have an important impact on the IH response to stents implanted in human coronary arteries. However, the differences in IH thickness between the analyzed stents were relatively small compared with the absolute lumen dimensions.