Enhancing effect of corticotropin-releasing neurohormone on the production of interleukin-1 and interleukin-2

• Published in: Neuroscience letters Vol. 120; no. 2; p. 151
• Main Authors: Singh, V K, Leu, S J
• Format: Journal Article
• Language: English
• Published: Ireland 11.12.1990
• Subjects: Adult; Animals; Cell Line; Cells, Cultured; Corticotropin-Releasing Hormone - pharmacology; Dose-Response Relationship, Drug; Humans; Interleukin-1 - biosynthesis; Interleukin-1 - blood; Interleukin-2 - biosynthesis; Interleukin-2 - blood; Kinetics; Leukocytes, Mononuclear - drug effects; Leukocytes, Mononuclear - immunology; Lymphocyte Activation; Mice; Reference Values; T-Lymphocytes - drug effects; T-Lymphocytes - immunology

Based upon an immunomodulatory role for Corticotropin-Releasing Factor (CRF), a low molecular weight neurohormone, we investigated the effect of CRF on the production of interleukin-1 (IL-1) and interleukin-2 (IL-2) activities of mononuclear cells isolated from the peripheral blood of healthy subjec...