Enhancing effect of corticotropin-releasing neurohormone on the production of interleukin-1 and interleukin-2

Based upon an immunomodulatory role for Corticotropin-Releasing Factor (CRF), a low molecular weight neurohormone, we investigated the effect of CRF on the production of interleukin-1 (IL-1) and interleukin-2 (IL-2) activities of mononuclear cells isolated from the peripheral blood of healthy subjec...

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Bibliographic Details
Published inNeuroscience letters Vol. 120; no. 2; p. 151
Main Authors Singh, V K, Leu, S J
Format Journal Article
LanguageEnglish
Published Ireland 11.12.1990
Subjects
Adult
Animals
Cell Line
Cells, Cultured
Corticotropin-Releasing Hormone - pharmacology
Dose-Response Relationship, Drug
Humans
Interleukin-1 - biosynthesis
Interleukin-1 - blood
Interleukin-2 - biosynthesis
Interleukin-2 - blood
Kinetics
Leukocytes, Mononuclear - drug effects
Leukocytes, Mononuclear - immunology
Lymphocyte Activation
Mice
Reference Values
T-Lymphocytes - drug effects
T-Lymphocytes - immunology
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Summary:Based upon an immunomodulatory role for Corticotropin-Releasing Factor (CRF), a low molecular weight neurohormone, we investigated the effect of CRF on the production of interleukin-1 (IL-1) and interleukin-2 (IL-2) activities of mononuclear cells isolated from the peripheral blood of healthy subjects. The production of both IL-1 and IL-2 was stimulated by a nanomolar concentration of CRF by itself. In addition, CRF augmented the production of IL-1 as induced by lipopolysaccharide and the production of IL-2 as induced by phytohemagglutinin. These results suggest that CRF modulates the function of the cells of the immune system presumably by acting as a blood-borne mediator of the neuroendocrine-immune pathways.
ISSN:0304-3940
DOI:10.1016/0304-3940(90)90025-5