Review of Alternative Carrier Materials for Ocular Surface Reconstruction

Abstract Severe ocular surface disorders can result in deficiency of limbal stem cells that is potentially associated with chronic inflammation, impaired vision and even blindness. Advanced stem cells deficiency requires reconstruction of the OS with autologous or allogeneic limbal stem cells. To ad...

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Published inCurrent eye research Vol. 39; no. 6; pp. 541 - 552
Main Authors Feng, Yaqing, Borrelli, Maria, Reichl, Stephan, Schrader, Stefan, Geerling, Gerd
Format Journal Article
LanguageEnglish
Published England Informa Healthcare USA, Inc 01.06.2014
Taylor & Francis
Subjects
Amnion
Amniotic membrane
Animals
biomaterial
Cell Culture Techniques
Epithelial Cells - cytology
Humans
Limbus Corneae - cytology
ocular surface
reconstruction
Reconstructive Surgical Procedures
Stem Cell Transplantation
Stem Cells - cytology
tissue engineering
Tissue Engineering - methods
Tissue Scaffolds
Online AccessGet full text
ISSN0271-3683
1460-2202
1460-2202
DOI10.3109/02713683.2013.853803

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Abstract Abstract Severe ocular surface disorders can result in deficiency of limbal stem cells that is potentially associated with chronic inflammation, impaired vision and even blindness. Advanced stem cells deficiency requires reconstruction of the OS with autologous or allogeneic limbal stem cells. To address such deficiency, a limbal tissue biopsy is taken and limbal cells are expanded on a carrier, which then can be used for OS reconstruction. Human amniotic membrane - currently the most common carrier for transplantation of limbal epithelial stem cells - has the downsides of carrying the risk of disease transmission, limited transparency, variable and unstable quality and low mechanical strength. This article reviews the advantages and disadvantages of the established carrier materials for limbal stem cell transplantation, as well as discussing emerging alternatives, including carriers based on collagen, fibrin, siloxane hydrogel contact lenses, poly( -caprolactone), gelatin-chitosan, silk fibroin, human anterior lens capsule, keratin, poly(lactide-co-glycolide), polymethacrylate, hydroxyethylmethacrylate and poly(ethylene glycol) for their potential use in the treatment of limbal stem cell deficiency.
AbstractList Abstract Severe ocular surface disorders can result in deficiency of limbal stem cells that is potentially associated with chronic inflammation, impaired vision and even blindness. Advanced stem cells deficiency requires reconstruction of the OS with autologous or allogeneic limbal stem cells. To address such deficiency, a limbal tissue biopsy is taken and limbal cells are expanded on a carrier, which then can be used for OS reconstruction. Human amniotic membrane - currently the most common carrier for transplantation of limbal epithelial stem cells - has the downsides of carrying the risk of disease transmission, limited transparency, variable and unstable quality and low mechanical strength. This article reviews the advantages and disadvantages of the established carrier materials for limbal stem cell transplantation, as well as discussing emerging alternatives, including carriers based on collagen, fibrin, siloxane hydrogel contact lenses, poly( -caprolactone), gelatin-chitosan, silk fibroin, human anterior lens capsule, keratin, poly(lactide-co-glycolide), polymethacrylate, hydroxyethylmethacrylate and poly(ethylene glycol) for their potential use in the treatment of limbal stem cell deficiency.
Severe ocular surface disorders can result in deficiency of limbal stem cells that is potentially associated with chronic inflammation, impaired vision and even blindness. Advanced stem cells deficiency requires reconstruction of the OS with autologous or allogeneic limbal stem cells. To address such deficiency, a limbal tissue biopsy is taken and limbal cells are expanded on a carrier, which then can be used for OS reconstruction. Human amniotic membrane - currently the most common carrier for transplantation of limbal epithelial stem cells - has the downsides of carrying the risk of disease transmission, limited transparency, variable and unstable quality and low mechanical strength. This article reviews the advantages and disadvantages of the established carrier materials for limbal stem cell transplantation, as well as discussing emerging alternatives, including carriers based on collagen, fibrin, siloxane hydrogel contact lenses, poly(ε-caprolactone), gelatin-chitosan, silk fibroin, human anterior lens capsule, keratin, poly(lactide-co-glycolide), polymethacrylate, hydroxyethylmethacrylate and poly(ethylene glycol) for their potential use in the treatment of limbal stem cell deficiency.Severe ocular surface disorders can result in deficiency of limbal stem cells that is potentially associated with chronic inflammation, impaired vision and even blindness. Advanced stem cells deficiency requires reconstruction of the OS with autologous or allogeneic limbal stem cells. To address such deficiency, a limbal tissue biopsy is taken and limbal cells are expanded on a carrier, which then can be used for OS reconstruction. Human amniotic membrane - currently the most common carrier for transplantation of limbal epithelial stem cells - has the downsides of carrying the risk of disease transmission, limited transparency, variable and unstable quality and low mechanical strength. This article reviews the advantages and disadvantages of the established carrier materials for limbal stem cell transplantation, as well as discussing emerging alternatives, including carriers based on collagen, fibrin, siloxane hydrogel contact lenses, poly(ε-caprolactone), gelatin-chitosan, silk fibroin, human anterior lens capsule, keratin, poly(lactide-co-glycolide), polymethacrylate, hydroxyethylmethacrylate and poly(ethylene glycol) for their potential use in the treatment of limbal stem cell deficiency.
Severe ocular surface disorders can result in deficiency of limbal stem cells that is potentially associated with chronic inflammation, impaired vision and even blindness. Advanced stem cells deficiency requires reconstruction of the OS with autologous or allogeneic limbal stem cells. To address such deficiency, a limbal tissue biopsy is taken and limbal cells are expanded on a carrier, which then can be used for OS reconstruction. Human amniotic membrane - currently the most common carrier for transplantation of limbal epithelial stem cells - has the downsides of carrying the risk of disease transmission, limited transparency, variable and unstable quality and low mechanical strength. This article reviews the advantages and disadvantages of the established carrier materials for limbal stem cell transplantation, as well as discussing emerging alternatives, including carriers based on collagen, fibrin, siloxane hydrogel contact lenses, poly(ε-caprolactone), gelatin-chitosan, silk fibroin, human anterior lens capsule, keratin, poly(lactide-co-glycolide), polymethacrylate, hydroxyethylmethacrylate and poly(ethylene glycol) for their potential use in the treatment of limbal stem cell deficiency.
Author Borrelli, Maria
Geerling, Gerd
Schrader, Stefan
Reichl, Stephan
Feng, Yaqing
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  surname: Borrelli
  fullname: Borrelli, Maria
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  organization: Department of Ophthalmology, University of Düsseldorf
– sequence: 3
  givenname: Stephan
  surname: Reichl
  fullname: Reichl, Stephan
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  givenname: Stefan
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  fullname: Geerling, Gerd
  email: geerling@med.uni-duesseldorf.de, geerling@med.uni-duesseldorf.de
  organization: Department of Ophthalmology, University of Düsseldorf
BackLink https://www.ncbi.nlm.nih.gov/pubmed/24405104$$D View this record in MEDLINE/PubMed
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Snippet Abstract Severe ocular surface disorders can result in deficiency of limbal stem cells that is potentially associated with chronic inflammation, impaired...
Severe ocular surface disorders can result in deficiency of limbal stem cells that is potentially associated with chronic inflammation, impaired vision and...
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SubjectTerms Amnion
Amniotic membrane
Animals
biomaterial
Cell Culture Techniques
Epithelial Cells - cytology
Humans
Limbus Corneae - cytology
ocular surface
reconstruction
Reconstructive Surgical Procedures
Stem Cell Transplantation
Stem Cells - cytology
tissue engineering
Tissue Engineering - methods
Tissue Scaffolds
Title Review of Alternative Carrier Materials for Ocular Surface Reconstruction
URI https://www.tandfonline.com/doi/abs/10.3109/02713683.2013.853803
https://www.ncbi.nlm.nih.gov/pubmed/24405104
https://www.proquest.com/docview/1522681604
Volume 39
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