Sesquiterpene Lactones from Artemisia absinthium . Biotransformation and Rearrangement of the Insect Antifeedant 3α-hydroxypelenolide

Three new compounds, the sesquiterpenes absilactone and hansonlactone and the acetophenone derivative ajenjol, have been isolated from a cultivated variety of . In addition, the major lactone isolated, 3α-hydroxypelenolide, was biotransformed by the fungus affording the corresponding 1β, 10α-epoxide...

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Bibliographic Details
Published inPlants (Basel) Vol. 10; no. 5; p. 891
Main Authors Fraga, Braulio M, Díaz, Carmen E, Bailén, María, González-Coloma, Azucena
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 28.04.2021
MDPI
Subjects
absilactone
Acetophenone
ajenjol
Artemisia absinthium
asteraceae
Biotransformation
Carbon
Cell culture
Cytotoxicity
Domestication
Experiments
Fungi
hansonlactone
Insect cells
Insects
Lactones
Mucor plumbeus
Sesquiterpene lactones
Sesquiterpenes
Artemisia absinthium
biotransformation
biological activity
ajenjol
3α-hydroxypelenolide
asteraceae
Mucor plumbeus
absilactone
hansonlactone
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Summary:Three new compounds, the sesquiterpenes absilactone and hansonlactone and the acetophenone derivative ajenjol, have been isolated from a cultivated variety of . In addition, the major lactone isolated, 3α-hydroxypelenolide, was biotransformed by the fungus affording the corresponding 1β, 10α-epoxide. A cadinane derivative was formed by an acid rearrangement produced in the culture medium, but not by the enzymatic system of the fungus. Furthermore, 3α-hydroxypelenolide showed strong antifeedant effects against and cytotoxic activity to Sf9 insect cells while the biotransformed compounds showed antifeedant postingestive effects against
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ISSN:2223-7747
2223-7747
DOI:10.3390/plants10050891