Efficacy of low doses of praziquantel in taeniasis

Early experimental studies suggested that doses of 1 to 5 mg of praziquantel (PZQ) per kg are effective against several intestinal cestodiases. The usually recommended single dose of PZQ in human taeniasis is 5 or 10 mg/kg. A study in T. saginata taeniasis showed a full efficacy at a dose of 2.5 mg/...

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Bibliographic Details
Published inActa Tropica Vol. 48; no. 2; pp. 83 - 88
Main Author Pawowski, Zbigniew S
Format Book Review Journal Article
LanguageEnglish
Published Amsterdam Elsevier B.V 01.12.1990
Elsevier
Subjects
Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiparasitic agents
Biological and medical sciences
Humans
Low dose
Medical sciences
Pharmacology. Drug treatments
Praziquantel
Praziquantel - administration & dosage
Praziquantel - therapeutic use
Taeniasis - drug therapy
Taeniasis in man
Praziquantel
Low dose
Taeniasis in man
Cestod disease
Infection
Human
Chemotherapy
Anthelmintic
Treatment
Digestive diseases
Teniasis
Helminthiasis
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Summary:Early experimental studies suggested that doses of 1 to 5 mg of praziquantel (PZQ) per kg are effective against several intestinal cestodiases. The usually recommended single dose of PZQ in human taeniasis is 5 or 10 mg/kg. A study in T. saginata taeniasis showed a full efficacy at a dose of 2.5 mg/kg. A field study confirmed that a dose between 3.4 and 7.5 mg/kg was effective in expulsion T. solium tapeworms in man. A dose of 2.5 mg of PZQ per kg would be safer and more economical in population-oriented interventions aiming at control of T. solium taeniasis in man.
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ISSN:0001-706X
1873-6254
DOI:10.1016/0001-706X(90)90046-3