Updates on androgen replacement therapy and lower urinary tract symptoms: a narrative review

Lower urinary tract symptoms (LUTS) are caused by higher tension at the bladder neck level (due to fibrosis or stiffness) or benign prostatic hyperplasia, which causes static obstruction of the bladder outlet. Both forms cause a group of symptoms such as hesitancy, intermittency, weak stream, noctur...

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Published inThe aging male Vol. 25; no. 1; pp. 234 - 241
Main Authors Al-Zoubi, Raed M., Alwani, Mustafa, Aboumarzouk, Omar M., Elaarag, Mai, Al-Qudimat, Ahmad R., Ojha, Laxmi, Yassin, Aksam
Format Journal Article
LanguageEnglish
Published Boca Raton Taylor & Francis 31.12.2022
Taylor & Francis Ltd
Taylor & Francis Group
Subjects
Aging
androgen
BPH
Endocrine therapy
hypogonadism
LUTS
Mens health
Older people
Prostate
Side effects
TRT
Urinary incontinence
Urinary retention
Urination
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Summary:Lower urinary tract symptoms (LUTS) are caused by higher tension at the bladder neck level (due to fibrosis or stiffness) or benign prostatic hyperplasia, which causes static obstruction of the bladder outlet. Both forms cause a group of symptoms such as hesitancy, intermittency, weak stream, nocturia, urine frequency, and urgency. Additionally, LUTS (obstructive or irritative symptoms) are common in elderly men with hypogonadism, identified as the reduced testes capability in producing sex steroids and sperm, and are categorized as testosterone deficiency. Even though the mode of action (MoA) of testosterone therapy (TTh) on hypogonadal men needs more researched and understanding, the effectiveness of TTh in the development of male genital organs has been reported in several studies. This review shows the latest updates of TTh in LUTS including potential adverse effects, advantages, and disadvantages.
Bibliography:ObjectType-Article-2
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ISSN:1368-5538
1473-0790
DOI:10.1080/13685538.2022.2118253