Origin, distribution and morphology of serotonergic afferents to the mesencephalic trigeminal nucleus of the rat

We have studied the localization, the morphology and sources of serotonergic input on the primary afferent neurons in the mesencephalic trigeminal nucleus (Me5) of the rat with light and electronmicroscopy immunocytochemistry and with anterograde and retrograde neuroanatomical tract tracing methods....

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Bibliographic Details
Published inNeuroscience letters Vol. 121; no. 1-2; p. 97
Main Authors Copray, J C, Liem, R S, Ter Horst, G J, van Willigen, J D
Format Journal Article
LanguageEnglish
Published Ireland 02.01.1991
Subjects
Animals
Horseradish Peroxidase
Immunohistochemistry
Male
Mesencephalon - ultrastructure
Microscopy, Immunoelectron
Neurons, Afferent - ultrastructure
Phytohemagglutinins
Raphe Nuclei - ultrastructure
Rats
Rats, Inbred Strains
Serotonin - physiology
Stereotaxic Techniques
Trigeminal Nuclei - ultrastructure
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Summary:We have studied the localization, the morphology and sources of serotonergic input on the primary afferent neurons in the mesencephalic trigeminal nucleus (Me5) of the rat with light and electronmicroscopy immunocytochemistry and with anterograde and retrograde neuroanatomical tract tracing methods. Me5 neurons were found to receive a serotonergic input that is part of a serotonergic fibre plexus extending over the neighbouring parabrachial nucleus and locus coeruleus. These serotonergic afferents originate predominantly from serotonergic cells in the dorsal raphe nucleus.
ISSN:0304-3940
1872-7972
DOI:10.1016/0304-3940(91)90658-G