Transient elastography as a noninvasive assessment tool for hepatopathies of different etiology in pediatric type 1 diabetes mellitus

• Published in: Journal of diabetes and its complications Vol. 31; no. 1; pp. 186 - 194
• Main Authors: Elkabbany, Zeinab A, Elbarbary, Nancy S, Ismail, Eman A, Mohamed, Nesrine A, Ragab, Dina, Alem, Sheren Abdel, Ezzat, Yasmine M, Maurice, Sarah S, Hashem, Noha U
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2017; Elsevier Limited
• Subjects: Adolescent; Age; Autoimmune hepatitis; Biomarkers; Biomarkers - blood; Biopsy; Blood pressure; Body mass index; Cholesterol; Cross-Sectional Studies; Diabetes; Diabetes Mellitus, Type 1 - blood; Diabetes Mellitus, Type 1 - complications; Diabetes Mellitus, Type 1 - therapy; Egypt - epidemiology; Elasticity Imaging Techniques; Endocrinology & Metabolism; Family medical history; Fasting; Female; Females; Glucose; Glycated Hemoglobin A - analysis; Hepacivirus - isolation & purification; Hepatic Insufficiency - complications; Hepatic Insufficiency - diagnostic imaging; Hepatic Insufficiency - pathology; Hepatic Insufficiency - virology; Hepatitis; Hepatitis C; Hepatitis C - complications; Hepatitis C - epidemiology; Hepatitis C - pathology; Hepatitis C - virology; Hepatitis, Autoimmune - complications; Hepatitis, Autoimmune - epidemiology; Hepatitis, Autoimmune - pathology; Hepatitis, Autoimmune - virology; Hepatomegaly - complications; Hepatomegaly - diagnostic imaging; Hepatomegaly - epidemiology; Hepatomegaly - pathology; Humans; Hyperglycemia - prevention & control; Hypoglycemia - prevention & control; Incidence; Infections; Insulin; Laboratories; Lipoproteins; Liver - diagnostic imaging; Liver - pathology; Liver - virology; Liver diseases; Liver stiffness; Male; NAFLD; Patients; Pediatrics; Prevalence; Proteins; Rodents; Standard deviation; Transient elastography; Type 1 diabetes; Ultrasonic imaging; Ultrasonography; liver stiffness; transient elastography; type 1 diabetes; NAFLD; autoimmune hepatitis; hepatitis C; Liver stiffness; Autoimmune hepatitis; Transient elastography; Hepatitis C; Type 1 diabetes
• ISSN: 1056-8727; 1873-460X
• DOI: 10.1016/j.jdiacomp.2016.09.009

Abstract Aim To identify the prevalence and effect of hepatopathies of different etiologies among pediatric patients with type 1 diabetes mellitus (T1DM) using transient elastography (TE) and its relation to glycemic control. Methods One hundred T1DM patients were studied focusing on liver functions, fasting lipid profile, hemoglobin A1c (HbA1c), hepatitis C virus (HCV), serum immunoglobulins, autoimmune antibodies; anti-nuclear antibody (ANA), anti-smooth muscle antibody (ASMA), and anti-liver kidney microsomal antibody (anti-LKM). Abdominal ultrasound was performed and TE was done for patients with HCV, positive autoimmune antibody and/or abnormal ultrasound findings. Results Thirty-one patients were found to have one or more hepatic abnormalities; clinical hepatomegaly in 8%, elevated alanine aminotransferase (ALT) in 10%, HCV in 6%, autoimmune hepatitis (AIH) in 11% (10 were positive for ASMA and 2 were positive for ANA while anti-LKM antibodies were negative) and abnormal hepatic ultrasound in 20% (12 non-alcoholic fatty liver disease, 5 AIH, 2 HCV, 1 Mauriac Syndrome). Mean liver stiffness in those 31 patients was 7.0 ± 2.1 kPa (range, 3.1–11.8 kPa); 24 were Metavir F0-F1, 7 were F2-F3 while none was F4. Type 1 diabetic patients with abnormal hepatic ultrasound had higher fasting blood glucose, HbA1c and total cholesterol than those with normal findings. Liver stiffness was significantly higher in patients with abnormal liver ultrasound compared with normal sonography. Liver stiffness was positively correlated to HbA1c and ALT. Conclusions Hepatic abnormalities are prevalent in T1DM and related to poor metabolic control. TE provides a non-invasive method for detection of hepatopathy-induced fibrosis.