Extracellular miRNAs as biomarkers in cancer

Cancer is the leading cause of death worldwide. Despite significant progress in the field leading to identification of molecular signatures of individual tumors and the development of targeted therapies, early cancer diagnosis remains a clinical challenge. The emerging era of personalized medicine h...

Full description

Saved in:
Bibliographic Details
Published inFood and chemical toxicology Vol. 98; no. Pt A; pp. 66 - 72
Main Authors Barger, Jennifer F., Rahman, Mohammad A., Jackson, Devine, Acunzo, Mario, Nana-Sinkam, S. Patrick
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.12.2016
Subjects
Animals
Biomarker
Biomarkers, Tumor - genetics
Cancer
Clinical trial
Exosome
Extracellular vesicle
Extracellular Vesicles - genetics
Extracellular Vesicles - pathology
Humans
MicroRNA
MicroRNAs - genetics
Neoplasms - diagnosis
Neoplasms - genetics
Clinical trial
Biomarker
MicroRNA
Extracellular vesicle
Exosome
Cancer
Online AccessGet full text

Cover

More Information
Summary:Cancer is the leading cause of death worldwide. Despite significant progress in the field leading to identification of molecular signatures of individual tumors and the development of targeted therapies, early cancer diagnosis remains a clinical challenge. The emerging era of personalized medicine has intensified research towards biomarkers that can be obtained via noninvasive means. The recent discovery of extracellular vesicles (EVs), nano-vesicles secreted by the cell, in circulation has stimulated interest in their clinical utility as cancer biomarkers. EVs are secreted from all types of cells and their contents reflect the physiological and pathological state of the cell. Multiple clinical trials are underway investigating the clinical potential of EV content to serve as biomarkers and therapeutics. However, much work remains to translate EV content into clinical application.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0278-6915
1873-6351
DOI:10.1016/j.fct.2016.06.010