Regulation of the Mammalian Nervous System by MicroRNAs

The mammalian nervous system exerts essential control on many physiological processes in the organism and is itself controlled extensively by a variety of genetic regulatory mechanisms. MicroRNAs, a class of small, noncoding RNAs, are critical contributors to the regulation of gene expression in the...

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Published inMolecular pharmacology Vol. 75; no. 2; pp. 259 - 264
Main Author Zeng, Yan
Format Journal Article
LanguageEnglish
Published United States American Society for Pharmacology and Experimental Therapeutics 01.02.2009
Subjects
Animals
Biological Phenomena
Evolution, Molecular
Gene Expression Regulation, Developmental
Mammals
MicroRNAs - biosynthesis
MicroRNAs - genetics
MicroRNAs - physiology
Minireview
Nervous System - growth & development
Nervous System Diseases - metabolism
RNA - metabolism
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Summary:The mammalian nervous system exerts essential control on many physiological processes in the organism and is itself controlled extensively by a variety of genetic regulatory mechanisms. MicroRNAs, a class of small, noncoding RNAs, are critical contributors to the regulation of gene expression in the nervous system. Emerging evidence indicates that microRNAs regulate both the development and function of the nervous system. Deficiency in microRNA function has also been implicated in a number of neurological disorders. Understanding the roles of microRNAs will provide new insights into the complexity and operation of the nervous system.
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Address correspondence to: Dr. Yan Zeng, 6-120 Jackson Hall, 321 Church Street SE, Department of Pharmacology, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455. E-mail: zengx033@umn.edu.
ABBREVIATIONS: miRNA, microRNA; Limk1, lim-domain containing protein kinase 1.
This work was supported in part by the National Institutes of Health National Institute on Drug Abuse [Grant P50-DA011806] and the Minnesota Medical Foundation [Grant 3674-9227-06].
ISSN:0026-895X
1521-0111
DOI:10.1124/mol.108.052118