Tessaria absinthioides (Hook. & Arn.) DC. (Asteraceae) Decoction Improves the Hypercholesterolemia and Alters the Expression of LXRs in Rat Liver and Hypothalamus

• Published in: Metabolites Vol. 11; no. 9; p. 579
• Main Authors: Rey, Mariana, Kruse, María S, Magrini-Huamán, Rocío N, Gómez, Jessica, Simirgiotis, Mario J, Tapia, Alejandro, Feresin, Gabriela E, Coirini, Héctor
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 27.08.2021; MDPI
• Subjects: Asteraceae; brain lipid metabolism; caffeoylquinic acid; Cholesterol; Diet; dietary fat; Flavonoids; Food; High cholesterol diet; High density lipoprotein; High fat diet; Hypercholesterolemia; Hypothalamus; Lipids; Liquid chromatography; Liver; Liver X receptors; Metabolism; nuclear receptors (LXR, PPAR, RXR); Tessaria absinthioides; triglyceride metabolism; Triglycerides; UHPLC-PDA-OT-MS/MS phenolic compounds analysis; caffeoylquinic acid; triglyceride metabolism; nuclear receptors (LXR, PPAR, RXR); UHPLC-PDA-OT-MS/MS phenolic compounds analysis; dietary fat; brain lipid metabolism
• ISSN: 2218-1989; 2218-1989
• DOI: 10.3390/metabo11090579

Chronic high-fat diet consumption induces hypercholesterolemia. The effect of (Hook. & Arn.) DC. (Asteraceae) was studied on the levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-c), and triglycerides, and on the expression of liver X receptors (LXRs) in a hypercholesterolemic model. Adult male rats received a normal diet (ND) or a high-fat diet (HFD; normal diet + bovine fat + cholesterol). After 14 days, rats received water (W) or a decoction of the aerial parts of (Ta; 10% / ) for 2, 4, or 6 weeks. Four and six weeks of Ta improved the levels of TC and HDL-c in HFD. After 6 weeks of Ta, the expression of LXRs in HFD was the same as that in ND in both tissues. The Ta chemical profile was studied with an ultrahigh resolution liquid chromatography Orbitrap MS analysis (UHPLC-PDA-OT-MS/MS). Fifty-one compounds were identified, of which twelve are reported for the first time. Among these compounds, caffeoylquinic acid and its derivatives could modify the lipid profile and the expression of LXRs. This is the first report of , which may be a potential candidate against hypercholesterolemia.