Cytotoxic Effects of Some Nepeta Species against Breast Cancer Cell Lines and Their Associated Phytochemical Properties

is one of the largest genera of the Lamiaceae family. species are commonly employed in traditional medicine for a variety of ailments, as well as food additives. In addition, they also come to the fore with their rich phytochemical content. In the present study, the quantitative phytochemical conten...

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Published inPlants (Basel) Vol. 11; no. 11; p. 1427
Main Authors Köngül Şafak, Esra, Şeker Karatoprak, Gökçe, Dirmenci, Tuncay, Duman, Hayri, Küçükboyacı, Nurgün
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 27.05.2022
MDPI
Subjects
Anticancer properties
antiproliferative effect
Antitumor activity
Breast cancer
Cytotoxicity
Estrogens
Flavonoids
Food additives
High-performance liquid chromatography
Investigations
Liquid chromatography
Nepeta
Phytochemicals
Species
Statistical analysis
Sterols
triterpenoid
Tumor cell lines
Ursolic acid
Turkey
triterpenoid
antiproliferative effect
Nepeta
ursolic acid
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Summary:is one of the largest genera of the Lamiaceae family. species are commonly employed in traditional medicine for a variety of ailments, as well as food additives. In addition, they also come to the fore with their rich phytochemical content. In the present study, the quantitative phytochemical content of methanolic extracts and infusions prepared from the aerial parts of 14 taxa collected from Turkey and their cytotoxic effects on two breast cancer cell lines, MCF-7 and MDA-MB-231, were investigated by using the MTT (3-(4,5-dimethylthiazol-2-yl))-2,5-diphenyltetrazolium-bromide) test. According to HPLC-PDA analysis, methanolic extract had the highest ursolic acid content with 165.9 mg/g extract. Total sterol, total iridoid, and total triterpenoid content were determined to be greatest in the methanolic extracts of and . The MTT experiment demonstrated that certain species suppressed the growth of MCF-7 and MDA-MB-231 cells in a dose-dependent manner. Statistical analysis revealed a strong correlation between the cytotoxic effects of the extracts and their triterpene content. In conclusion, the data obtained from this study are important in terms of forming a basis for advanced anticancer activity studies on breast cancer with sp.
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ISSN:2223-7747
2223-7747
DOI:10.3390/plants11111427