Burns in a suicide attempt related to psychiatric side effects of interferon

• Published in: Burns Vol. 24; no. 6; pp. 581 - 583
• Main Authors: Fukunishi, K., Tanaka, H., Maruyama, J., Takahashi, H., Kitagishi, H., Ueshima, T., Maruyama, K., Sakata, I.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.09.1998; Elsevier Science
• Subjects: Antiviral Agents - adverse effects; Biological and medical sciences; Burns; Burns - drug therapy; Burns - etiology; Burns - surgery; Depression; Depression - chemically induced; Depression - complications; Depression - psychology; Drug toxicity and drugs side effects treatment; Female; Fires; Follow-Up Studies; Hepatitis; Hepatitis C - therapy; Humans; Interferon; Interferon-alpha - adverse effects; Medical sciences; Middle Aged; Ointments - therapeutic use; Pharmacology. Drug treatments; Self Mutilation - psychology; Skin Transplantation; Suicide; Suicide, Attempted; Toxicity: nervous system and muscle; Hepatitis; Depression; Interferon; Burns; Suicide; Infection; Burn; Case study; Human; Toxicity; Viral disease; Mental disorder; Trauma; Viral hepatitis C; Suicide attempt
• ISSN: 0305-4179; 1879-1409
• DOI: 10.1016/S0305-4179(98)00073-4

A 50-year-old woman was admitted to our critical care center after pouring lamp oil on herself and setting herself on fire. Diagnosed with chronic hepatitis, she had received interferon-α at another hospital. During interferon therapy she developed anxiety, irritability, sleeplessness, and depression. At our hospital she underwent fluid resuscitation according to the method of Baxter. After treatment with topical cream and ointment, she underwent skin grafting. Interferon was not given. After discharge, wound healing proved satisfactory. She was intelligent and insightful, and her mental condition remained stable with no apparent emotional problems. As she had no significant past medical or psychiatric history and no history of substance abuse, we believe that her depression was a side effect of interferon therapy. A number of reports have described depression and other psychiatric disorders associated with interferon, but none of these accounts have concerned burns sustained in suicide attempts. This case underscores the potential seriousness of adverse reactions to interferon characterized by emotional disturbance and also illustrates that physicians who treat burn patients need to have an understanding of affective disorders and unusual side effects of medication.