Dilatation of Sinusoidal Capillary and Swelling of Sinusoidal Fenestration in Obesity: An Ultrastructural Study

• Published in: Ultrastructural pathology Vol. 39; no. 1; pp. 30 - 37
• Main Authors: Nakadate, Kazuhiko, Motojima, Kento, Tanaka-Nakadate, Sawako
• Format: Journal Article
• Language: English
• Published: England Informa Healthcare USA, Inc 01.02.2015; Informa Healthcare
• Subjects: Animals; Capillaries - ultrastructure; chronic obesity; Disease Models, Animal; Endothelium, Vascular - ultrastructure; Immunohistochemistry; Liver - ultrastructure; Male; Mice; Mice, Inbred C57BL; Microscopy, Electron, Scanning; monosodium glutamate; Non-alcoholic Fatty Liver Disease - pathology; nonalcoholic fatty liver disease; Obesity - pathology; scanning electron microscopy; sinusoidal endothelium; scanning electron microscopy; nonalcoholic fatty liver disease; monosodium glutamate; chronic obesity; sinusoidal endothelium
• ISSN: 0191-3123; 1521-0758
• DOI: 10.3109/01913123.2014.947010

Abstract Obesity, which is one of the causes of the lifestyle-related disease, is a hepatopathic exacerbation factor that causes a chronic hepatic disorder. In this study, we examined the pathological changes in the liver in mice with obesity induced by monosodium glutamate administration. Pathological analysis revealed the deposition of many lipid droplets in hepatocytes and sinusoidal dilatation in obese mice. Scanning electron microscopic analysis revealed the presence of sinusoidal dilatation, and the fenestrations of the sinusoid were significantly swollen in obese mice. These results suggest that a dysfunction of the sinusoidal endothelium occurs in chronic obesity.