Bio-functionalized dense-silica nanoparticles for MR/NIRF imaging of CD146 in gastric cancer

• Published in: International journal of nanomedicine Vol. 10; no. default; pp. 749 - 763
• Main Authors: Wang, Pu, Qu, Yazhuo, Li, Chuan, Yin, Li, Shen, Caifei, Chen, Wei, Yang, Shiming, Bian, Xiuwu, Fang, Dianchun
• Format: Journal Article
• Language: English
• Published: New Zealand Taylor & Francis Ltd 01.01.2015; Dove Press; Dove Medical Press
• Subjects: Angiogenesis; Animals; Antibodies, Monoclonal - chemistry; Antibodies, Monoclonal - immunology; Biocompatibility; Biomedical materials; Cancer therapies; CD146 Antigen - immunology; CD146 Antigen - metabolism; Cell Line, Tumor; Drug Delivery Systems; EMT; Esophagus; Female; Fluorescent Antibody Technique; Gastric cancer; Gastroenterology; Humans; Laboratory animals; Life sciences; Magnetic Resonance Imaging - methods; Medical prognosis; Metastasis; Mice; Mice, Nude; Microscopy, Confocal; Microscopy, Fluorescence - methods; Nanoparticles; Nanoparticles - chemistry; Nanotechnology; NMR; Nuclear magnetic resonance; Original Research; Patients; Silicon Dioxide - chemistry; Skin cancer; Spectrometry, Fluorescence - methods; SPION; SPION@dSiO2; Stomach Neoplasms - immunology; Stomach Neoplasms - metabolism; Stomach Neoplasms - pathology; Tumors; xenograft; United States > US; China; nanotechnology; gastric cancer; xenograft; SPION; EMT; SPION@dSiO2

Nano dense-silica (dSiO2) has many advantages such as adjustable core-shell structure, multiple drug delivery, and controllable release behavior. Improving the gastric tumor-specific targeting efficiency based on the development of various strategies is crucial for anti-cancer drug delivery systems....