Anti-Obesity Effects of Ecklonia cava Extract in High-Fat Diet-Induced Obese Rats

• Published in: Antioxidants Vol. 11; no. 2; p. 310
• Main Authors: Abbas, Muhammad Aleem, Boby, Naila, Lee, Eon-Bee, Hong, Joo-Heon, Park, Seung-Chun
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 03.02.2022; MDPI
• Subjects: 3T3-L1; Adipocytes; Adipose tissue; Algae; Animal models; anti-obesity; Biomarkers; Body weight; brown alga; COVID-19; Diabetes; Diet; Dietary supplements; Disease; Ecklonia cava; Ethanol; Fatty liver; Fetal alcohol syndrome; Food intake; High density lipoprotein; High fat diet; Insulin; Laboratory animals; leptin and ghrelin; Liver; Medical research; Metabolism; Obesity; Overweight; Pandemics; Peroxisome proliferator-activated receptors; Sterol regulatory element-binding protein; Weight control; South Korea; Japan; antioxidant; phlorotannin; liver biomarkers; ROC; anti-obesity; high-fat diet; Ecklonia cava; brown alga; leptin and ghrelin; 3T3-L1; obesity
• ISSN: 2076-3921; 2076-3921
• DOI: 10.3390/antiox11020310

Obesity is becoming a global epidemic as a result of high-calorie food intake and unhealthy lifestyles. Different marine plants, especially brown algae ( ), are traditionally used to treat different health-related issues. The study was carried out to investigate the anti-obesity properties of 70% ethanol extract. To evaluate the anti-obesity effect of , both in vitro and in vivo tests were performed. suppresses pre-adipocyte 3T3-L1 differentiation in a dose-dependent manner. In HFD-induced obese rats' models, administration of 125, 250, and 500 mg/kg significantly decreases total body weight and organs, especially liver weight, in all treatment groups. Adipose tissue weight, including subcutaneous, epididymal, peritoneal, and mesenteric adipose tissue, was markedly reduced in -treated HFD rats in dose-dependent manners. In addition, liver-related biomarkers AST, ALP, ALT, and GGT were evaluated; the lower level of liver-related biomarkers indicates no liver injury or fatty liver issue in HFD treatment groups. In addition, treatment has significant effects on the expression of adipogenic and lipogenic (PPAR-γ, FAS, LPL, and SREBP-1c) genes. Altogether, these results show the anti-obesity effect of . We concluded that could be a potential candidate for the prevention of obesity-induced by a high-fat diet.