Role of the placenta in developmental programming: Observations from models using large animals

Developmental programming, which proposes that “insults” or “stressors” during intrauterine or postnatal development can have not only immediate but also long-term consequences for healthy and productivity, has emerged as a major biological principle, and based on studies in many animal species also...

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Published inAnimal reproduction science Vol. 257; p. 107322
Main Authors Reynolds, L.P., Dahlen, C.R., Ward, A.K., Crouse, M.S., Borowicz, P.P., Davila-Ruiz, B.J., Kanjanaruch, C., Bochantin, K.A., McLean, K.J., McCarthy, K.L., Menezes, A.C.B., Diniz, W.J.S., Cushman, R.A., Caton, J.S.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.10.2023
Subjects
Animals
Blood flow
Developmental programming
Female
Fetal Development
Fetal growth
Function
Placenta
Pregnancy
Vascularity
Fetal growth
Function
Vascularity
Developmental programming
Placenta
Blood flow
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Summary:Developmental programming, which proposes that “insults” or “stressors” during intrauterine or postnatal development can have not only immediate but also long-term consequences for healthy and productivity, has emerged as a major biological principle, and based on studies in many animal species also seems to be a universal phenomenon. In eutherians, the placenta appears to be programmed during its development, which has consequences for fetal growth and development throughout pregnancy, and likewise has long-term consequences for postnatal development, leading to programming of organ function of the offspring even into adulthood. This review summarizes our current understanding of the placenta’s role in developmental programming, the mechanisms involved, and the challenges remaining.
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Author contribution statement
Reynolds LP: Writing, revision (editing) of manuscript, figures and table; Dahlen CR, Ward AK, Crouse MS, Borowicz PP, Dávila-Ruiz BJ, Kanjanaruch C, Bochantin KA, McLean KJ, McCarthy KL, Menezes ACB, Diniz WJS, Cushman RA, and Caton JS: Conceptualization, review, editing.
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ISSN:0378-4320
1873-2232
1873-2232
DOI:10.1016/j.anireprosci.2023.107322