Differential expression of thymic DNA repair genes in low-dose-rate irradiated AKR/J mice

• Published in: Journal of veterinary science (Suwŏn-si, Korea) Vol. 14; no. 3; pp. 271 - 279
• Main Authors: Bong, J.J., Korea Hydro and Nuclear Power, Seoul, Republic of Korea, Kang, Y.M., Korea Hydro and Nuclear Power, Seoul, Republic of Korea, Shin, S.C., Korea Hydro and Nuclear Power, Seoul, Republic of Korea, Choi, S.J., Korea Hydro and Nuclear Power, Seoul, Republic of Korea, LEe, K.M., Korea University, Seoul, Republic of Korea, Lee, H.S., Korea Hydro and Nuclear Power, Seoul, Republic of Korea
• Format: Journal Article
• Language: English
• Published: Korea (South) 대한수의학회 2013; The Korean Society of Veterinary Science
• Subjects: Animals; DNA Repair - radiation effects; Dose-Response Relationship, Radiation; Female; GENE; Gene Expression Regulation - radiation effects; Gene Regulatory Networks - radiation effects; GENES; Lymphoma - etiology; Lymphoma - genetics; Mice; Mice, Inbred AKR; Oligonucleotide Array Sequence Analysis; Original; Radiation, Ionizing; Reverse Transcriptase Polymerase Chain Reaction; thymic lymphoma,DNA repair genes; Thymus Gland - radiation effects; Thymus Neoplasms - etiology; Thymus Neoplasms - genetics; 수의학; DNA repair genes; thymic lymphoma; AKR/J mice; low-dose-rate radiation
• ISSN: 1229-845X; 1976-555X
• DOI: 10.4142/jvs.2013.14.3.271

We previously determined that AKR/J mice housed in a low-dose-rate r-irradiation facility developed less spontaneous thymic lymphoma and survived longer than those receiving sham or high-dose-rate radiation . Interestingly, historpathological analysis showed a mild lymphomagenesis in the thymus of LDR-irradiated mice.