Anti-Müllerian hormone as a possible predictor of fecundability in subfertile women over 38 years: a retrospective cohort study

• Published in: Gynecological endocrinology Vol. 31; no. 1; pp. 22 - 25
• Main Authors: Kato, Nao, Iwase, Akira, Sugita, Atsuko, Goto, Maki, Nakahara, Tatsuo, Nakamura, Tomoko, Kondo, Mika, Osuka, Satoko, Mori, Masahiko, Saito, Ai, Kikkawa, Fumitaka
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 01.01.2015; Informa Healthcare
• Subjects: Adult; Age Factors; Anti-Mullerian Hormone - blood; Anti-Müllerian hormone; Cohort Studies; fecundability; Female; Fertility - physiology; Fertilization in Vitro; Humans; infertility treatment; Infertility, Female - blood; Infertility, Female - diagnosis; long-term fertility; ovarian reserve; Predictive Value of Tests; Pregnancy; Prognosis; Retrospective Studies; fecundability; Anti-Müllerian hormone; ovarian reserve; infertility treatment; long-term fertility
• ISSN: 0951-3590; 1473-0766
• DOI: 10.3109/09513590.2014.943720

Abstract Anti-Müllerian hormone (AMH) is a relatively novel method for examining the ovarian reserve that reflects female reproductive function. In the era in which the number of women delaying attempts to conceive has increased, a good predictor for long-term fecundability has been explored. We performed the retrospective cohort study to investigate whether initial serum AMH levels are useful for predicting long-term fertility during infertility treatments. We recruited 149 women in the retrospective cohort, and 52 women were gravid during the follow-up period. According to the multiple logistic analyses, only age was found to have a significant correlation with pregnancy success in all women. In women 38 years, significantly higher serum AMH levels were detected in the pregnant group (median = 2.83 ng/mL, range = 1.11-6.29 ng/mL) than the non-pregnant group (median = 1.22 ng/mL, range = 0-9.46 ng/mL; p = 0.015). None of the women with serum AMH levels <0.7 ng/mL were pregnant during treatment. AMH may be used to identify poor pregnancy prospects in women who are above 38 years.