Risk Assessment of Side Branch Compromise After Coronary Bifurcation Stenting　― A Substudy of the 3D-OCT Bifurcation Registry

• Published in: Circulation Journal Vol. 88; no. 6; pp. 959 - 969
• Main Authors: Akase, Hideaki, Okamura, Takayuki, Nagoshi, Ryoji, Fujimura, Tatsuhiro, Miyazaki, Yosuke, Takenaka, Hitoshi, Matsuyama, Tetsuya, Murasato, Yoshinobu, Yamawaki, Masahiro, Ono, Shiro, Serikawa, Takeshi, Hikichi, Yutaka, Norita, Hiroaki, Nakao, Fumiaki, Sakamoto, Tomohiro, Shinke, Toshiro, Yano, Masafumi, Shite, Junya
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Circulation Society 24.05.2024
• Subjects: 3-Dimensional; Aged; Bifurcation; Coronary Angiography; Coronary Artery Disease - diagnostic imaging; Coronary Artery Disease - surgery; Coronary Artery Disease - therapy; Coronary Stenosis - diagnostic imaging; Coronary Stenosis - surgery; Coronary Stenosis - therapy; Coronary Vessels - diagnostic imaging; Female; Humans; Male; Middle Aged; Optical coherence tomography; Percutaneous coronary intervention; Registries; Risk Assessment; Side branch compromise; Stents - adverse effects; Tomography, Optical Coherence; Bifurcation; Percutaneous coronary intervention; 3-Dimensional; Optical coherence tomography; Side branch compromise
• ISSN: 1346-9843; 1347-4820; 1347-4820
• DOI: 10.1253/circj.CJ-22-0723

Background: Side branch (SB) occlusion during bifurcation stenting is a serious complication. This study aimed to predict SB compromise (SBC) using optical coherence tomography (OCT).Methods and Results: Among the 168 patients who enrolled in the 3D-OCT Bifurcation Registry, 111 bifurcation lesions were analyzed to develop an OCT risk score for predicting SBC. SBC was defined as worsening of angiographic SB ostial stenosis (≥90%) immediately after stenting. On the basis of OCT before stenting, geometric parameters (SB diameter [SBd], length from proximal branching point to carina tip [BP-CT length], and distance of the polygon of confluence [dPOC]) and 3-dimensional bifurcation types (parallel or perpendicular) were evaluated. SBC occurred in 36 (32%) lesions. The parallel-type bifurcation was significantly more frequent in lesions with SBC. The receiver operating characteristic curve indicated SBd ≤1.77 mm (area under the curve [AUC]=0.73, sensitivity 64%, specificity 75%), BP-CT length ≤1.8 mm (AUC=0.83, sensitivity 86%, specificity 68%), and dPOC ≤3.96 mm (AUC=0.68, sensitivity 63%, specificity 69%) as the best cut-off values for predicting SBC. To create the OCT risk score, we assigned 1 point to each of these factors. As the score increased, the frequency of SBC increased significantly (Score 0, 0%; Score 1, 8.7%; Score 2, 28%; Score 3, 58%; Score 4, 85%; P<0.0001).Conclusions: Prediction of SBC using OCT is feasible with high probability.