The Discovery of Druggable Anti-aging Agents

Caloric restriction (CR) has been shown to extend the lifespan of many species. Research to identify compounds that imitate the results of CR has shown extensions of both lifespan and healthspan via different mechanisms. For example, mechanistic target of rapamycin (mTOR) inhibitors such as rapamyci...

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Bibliographic Details
Published inAnnals of geriatric medicine and research Vol. 24; no. 4; pp. 232 - 242
Main Authors Yalcin, Gulperi, Lee, Cheol-Koo
Format Journal Article
LanguageEnglish
Published Korea (South) Korean Geriatrics Society 01.12.2020
Korea Geriatrics Society
대한노인병학회
Subjects
anti-aging
caloric restriction mimetics
Invited Review
lifespan extension
가정의학
Anti-aging
Caloric restriction mimetics
Lifespan extension
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Summary:Caloric restriction (CR) has been shown to extend the lifespan of many species. Research to identify compounds that imitate the results of CR has shown extensions of both lifespan and healthspan via different mechanisms. For example, mechanistic target of rapamycin (mTOR) inhibitors such as rapamycin, phenols, and flavonoids show antioxidant characteristics, while spermidine induces autophagy. Herein, we summarize research progress and proposed mechanisms for the most well-known compounds showing lifespan-extending potential for anti-aging characteristics.
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http://www.e-agmr.org/journal/view.php?doi=10.4235/agmr.20.0092
ISSN:2508-4798
2508-4909
DOI:10.4235/AGMR.20.0092