Neural mechanisms for generation of tactile interference effects on somatosensory evoked magnetic fields in humans

• Published in: Clinical Neurophysiology Vol. 113; no. 5; pp. 672 - 680
• Main Authors: Tanosaki, Masato, Suzuki, Atsushi, Takino, Ryosuke, Kimura, Tomoaki, Iguchi, Yoshinobu, Kurobe, Yuji, Haruta, Yasuhiro, Hoshi, Yoko, Hashimoto, Isao
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier B.V 01.05.2002; Elsevier BV; Elsevier Science
• Subjects: Adult; Biological and medical sciences; Digits; Electric Stimulation; Evoked Potentials, Somatosensory; Evoked Potentials, Somatosensory - physiology; Female; Fingers; Fingers - innervation; Fingers - physiology; Fundamental and applied biological sciences. Psychology; Humans; Integration; Intrinsic circuitry; Magnetoencephalography; Magnetoencephalography (MEG); Male; Neural Pathways; Pyramidal Cells; Pyramidal Cells - physiology; Somatosensory Cortex; Somatosensory Cortex - cytology; Somatosensory Cortex - physiology; Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors; Tactile interference; Touch; Touch - physiology; Vertebrates: nervous system and sense organs; Somatosensory cortex; Tactile interference; Magnetoencephalography (MEG); Integration; Intrinsic circuitry; Digits; Human; Magnetoencephalography; Electrical stimulus; Central nervous system; Finger; Interference; Electrophysiology; Tactile sensitivity; Somesthetic pathway; Somatosensory evoked potential; Magnetic field; Brain (vertebrata)
• ISSN: 1388-2457
• DOI: 10.1016/S1388-2457(02)00052-4

Objectives: We examined modification of somatosensory evoked fields following electric middle finger stimulation with interference to the same and surrounding digits in 13 subjects. Methods: During electric middle finger stimulation, concurrent tactile stimulation was applied to the middle finger, to the index and ring fingers, and to the thumb and the little finger, individually. Results: The amplitudes of the N20m and the P30m were significantly reduced by the interference to the middle finger, and to the index and ring fingers. The former interference induced more prominent attenuation than the latter. The amplitudes of the P60m did not show significant changes by any kind of the interference. Conclusions: The N20m and the P30m were attenuated according to the cortical distance between electrically and mechanically activated 3b areas. Pyramidal neurons are interconnected by intrinsic horizontal collaterals, even if their representations are segregated. The activation of the intrinsic collaterals induces direct excitation and indirect inhibition (via inhibitory interneurons) to the target pyramidal neurons. The result indicates that the activation of the intrinsic collaterals inhibits, on balance, the postsynaptic pyramidal targets, thereby generating the attenuation of the N20m and P30m.