Mesoporous silica nanoparticles in recent photodynamic therapy applications

• Published in: Photochemical & photobiological sciences Vol. 17; no. 11; pp. 1651 - 1674
• Main Authors: Bayir, Sumeyra, Barras, Alexandre, Boukherroub, Rabah, Szunerits, Sabine, Raehm, Laurence, Richeter, Sébastien, Durand, Jean-Olivier
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.11.2018; Royal Society of Chemistry; Springer
• Subjects: Alzheimer Disease - drug therapy; Alzheimer's disease; Antiinfectives and antibacterials; Arteriosclerosis; Atherosclerosis; Atherosclerosis - drug therapy; Bacteria - drug effects; Biochemistry; Biomaterials; Cancer; Chemical Sciences; Chemistry; Infrared radiation; Microorganisms; Nanoparticles; Nanoparticles - chemistry; Neoplasms - drug therapy; Neurodegenerative diseases; Particle Size; Photochemotherapy; Photodynamic therapy; Photosensitizing Agents - chemistry; Photosensitizing Agents - pharmacology; Physical Chemistry; Plant Sciences; Porosity; Silica; Silicon dioxide; Silicon Dioxide - chemistry; Silicon Dioxide - pharmacology; Surface Properties; Tin
• ISSN: 1474-905X; 1474-9092
• DOI: 10.1039/c8pp00143j

In this review, the use of mesoporous silica nanoparticles for photodynamic therapy (PDT) applications is described for the year 2017. Since the pioneering work in 2009, nanosystems involving mesoporous silica nanoparticles have gained in complexity with a sophisticated core-shell system able to perform multi-imaging and multi-therapies, not only for cancer diseases but also for anti-microbial therapy, atherosclerosis, or Alzheimer disease. Near-infrared, excitation light based on up-converting systems, X-rays or persistent luminescent systems are described for deeper tissue treatments. In this review, the use of mesoporous silica nanoparticles for photodynamic therapy (PDT) applications is described for the year 2017.