Predictive Accuracy of MCI Subtypes for Alzheimer’s Disease and Vascular Dementia in Subjects with Mild Cognitive Impairment: A 2-Year Follow-Up Study

• Published in: Dementia and geriatric cognitive disorders Vol. 19; no. 2-3; pp. 113 - 119
• Main Authors: Rasquin, S.M.C., Lodder, J., Visser, P.J., Lousberg, R., Verhey, F.R.J.
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland Karger 01.01.2005; S. Karger AG
• Subjects: Activities of Daily Living - classification; Activities of Daily Living - psychology; Aged; Aged, 80 and over; Alzheimer Disease - classification; Alzheimer Disease - diagnosis; Alzheimer Disease - epidemiology; Amnesia - classification; Amnesia - diagnosis; Amnesia - epidemiology; Biological and medical sciences; Blood. Blood coagulation. Reticuloendothelial system; Cognition Disorders - classification; Cognition Disorders - diagnosis; Cognition Disorders - epidemiology; Cohort Studies; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Dementia; Dementia, Multi-Infarct - classification; Dementia, Multi-Infarct - diagnosis; Dementia, Multi-Infarct - epidemiology; Dementia, Vascular - classification; Dementia, Vascular - diagnosis; Dementia, Vascular - epidemiology; Disease Progression; Female; Humans; Longitudinal Studies; Male; Medical sciences; Memory, Short-Term; Mental Status Schedule - statistics & numerical data; Middle Aged; Neurology; Neuropsychological Tests - statistics & numerical data; Original Research Article; Pharmacology. Drug treatments; Psychometrics - statistics & numerical data; Reproducibility of Results; Retention (Psychology); Risk; Vascular diseases and vascular malformations of the nervous system; Verbal Learning; Predementia stage; Vascular dementia; Mild cognitive impairment; Diagnostic criteria; Alzheimer's dementia; Human; Nervous system diseases; Cognitive disorder; Alzheimer disease; Cardiovascular disease; Cerebral disorder; Vascular disease; Follow up study; Central nervous system disease; mild cognitive impairment; Degenerative disease; Diagnosis; Dementia
• ISSN: 1420-8008; 1421-9824
• DOI: 10.1159/000082662

Aim: The aim of this study was to investigate the prognostic accuracy of different subtypes of mild cognitive impairment (MCI): amnestic MCI, multiple domain MCI, and single non-memory domain MCI, for the development of Alzheimer’s dementia (AD) and vascular dementia (VaD). Patients: Nondemented patients from a memory clinic cohort (n = 118), and a stroke cohort (n = 80, older than 55 years and with a cognitive impairment). Results: ‘Multiple domain MCI’ had the highest sensitivity for both AD (80.8%) and VaD (100%), and ‘amnestic MCI’ had the highest specificity (85.9% for AD, 100% for VaD). The positive predictive value was low for all subtypes (0.0–32.7%), whereas the negative predictive value was high (72.8–100%). Discussion: The subtype ‘multiple domain MCI’ has high sensitivity in identifying people at risk for developing AD or VaD. The predictive accuracy of the MCI subtypes was similar for both AD and VaD.