Role of oxidative stress in the pathogenesis of alcohol-induced liver disease

Abstract Chronic alcohol consumption is a well-known risk factor for liver disease, which represents a major cause of morbidity and mortality worldwide. The pathological process of alcohol-induced liver disease is characterized by a broad spectrum of morphological changes ranging from steatosis with...

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Bibliographic Details
Published inFree radical research Vol. 47; no. 11; pp. 894 - 904
Main Authors Sid, B., Verrax, J., Calderon, P. B.
Format Journal Article
LanguageEnglish
Published England Informa Healthcare 01.11.2013
Taylor & Francis
Subjects
alcohol
Alcohol Drinking - metabolism
Animals
Humans
liver disease
Liver Diseases, Alcoholic - metabolism
Liver Diseases, Alcoholic - pathology
oxidative damage
Oxidative Stress - physiology
reactive oxygen species
Reactive Oxygen Species - metabolism
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Summary:Abstract Chronic alcohol consumption is a well-known risk factor for liver disease, which represents a major cause of morbidity and mortality worldwide. The pathological process of alcohol-induced liver disease is characterized by a broad spectrum of morphological changes ranging from steatosis with minimal injury to more advanced liver damage, including steato-hepatitis and fibrosis/cirrhosis. Experimental and clinical studies increasingly show that the oxidative damage induced by ethanol contribute in many ways to the pathogenesis of alcohol hepatotoxicity. This article describes the contribution of oxidative mechanisms to liver damage by alcohol.
ISSN:1071-5762
1029-2470
DOI:10.3109/10715762.2013.819428