Exogenous lysozyme influences Clostridium perfringens colonization and intestinal barrier function in broiler chickens

• Published in: Avian pathology Vol. 39; no. 1; pp. 17 - 24
• Main Authors: Liu, Dan, Guo, Yuming, Wang, Zhong, Yuan, Jianmin
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis Group 01.02.2010; Taylor & Francis Ltd
• Subjects: Animal diseases; Animals; Anti-Infective Agents - administration & dosage; Anti-Infective Agents - metabolism; broiler chickens; broiler feeding; Chickens; Clostridium Infections - drug therapy; Clostridium Infections - metabolism; Clostridium Infections - microbiology; Clostridium Infections - pathology; Clostridium Infections - veterinary; Clostridium perfringens; Clostridium perfringens - drug effects; Clostridium perfringens - growth & development; Colonization; Dietary Supplements; duodenum; E coli; enzyme activity; Enzyme kinetics; Escherichia coli; Escherichia coli - drug effects; Escherichia coli - growth & development; Feed conversion; feed supplements; ileum; intestinal absorption; intestinal barrier function; Intestines - drug effects; Intestines - metabolism; Intestines - microbiology; Intestines - pathology; jejunum; Lactobacillus; Lactobacillus - drug effects; Lactobacillus - growth & development; Lesions; liveweight gain; lysozyme; microbial colonization; Muramidase - administration & dosage; Muramidase - metabolism; necrotic enteritis; Poultry; poultry diseases; Poultry Diseases - drug therapy; Poultry Diseases - metabolism; Poultry Diseases - microbiology; Poultry Diseases - pathology; Small intestine; spleen; Spleen - microbiology; Translocation; Weight Gain - drug effects

Necrotic enteritis is a worldwide poultry disease caused by the overgrowth of Clostridium perfringens in the small intestine. An experiment with a 22 factorial design (supplementation with or without 40 mg lysozyme/kg diet for chickens challenged with or without C. perfringens) was conducted to inve...