Insulin-like growth factor-I gene polymorphism and risk of heart failure (the Rotterdam Study)

We studied 4,963 participants of the population-based Rotterdam Study and found that a genetically determined chronic exposure to low insulin-like growth factor-I (IGF-I) levels is associated with an increased risk for heart failure in elderly patients.

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Bibliographic Details
Published inThe American journal of cardiology Vol. 94; no. 3; pp. 384 - 386
Main Authors Bleumink, Gysèle S, Rietveld, Ingrid, Janssen, Joop A.M..J.L, van Rossum, Elisabeth F.C, Deckers, Jaap W, Hofman, Albert, Witteman, Jacqueline C.M, van Duijn, Cornelia M, Stricker, Bruno H.Ch
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier Inc 01.08.2004
Elsevier
Elsevier Limited
Subjects
Age Distribution
Alleles
Biological and medical sciences
Cardiology
Cardiology. Vascular system
Cohort Studies
Confidence Intervals
Female
Genes
Genetic Predisposition to Disease
Health risk assessment
Heart
Heart failure
Heart Failure - epidemiology
Heart Failure - genetics
Heart failure, cardiogenic pulmonary edema, cardiac enlargement
Humans
Incidence
Insulin-Like Growth Factor I - genetics
Male
Medical sciences
Older people
Polymorphism
Polymorphism, Genetic
Prognosis
Promoter Regions, Genetic
Proportional Hazards Models
Prospective Studies
Risk Assessment
Sex Distribution
Survival Analysis
Heart failure
Gene
Heart disease
Risk factor
Cardiovascular disease
Risk
Circulatory system
Cardiology
Insulin like growth factor 1
Phlebology
Polymorphism
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Summary:We studied 4,963 participants of the population-based Rotterdam Study and found that a genetically determined chronic exposure to low insulin-like growth factor-I (IGF-I) levels is associated with an increased risk for heart failure in elderly patients.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2004.04.044