Brain diffusion changes in unilateral carotid artery stenosis with non-shunt endarterectomy: Correlation with white matter lesions

• Published in: Clinical neurology and neurosurgery Vol. 133; pp. 24 - 29
• Main Authors: Sahin, Neslin, Solak, Aynur, Genc, Berhan, Akpinar, Mehmet Besir, Kulu, Ugur, Cengiz, Hakan
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.06.2015; Elsevier Limited
• Subjects: Aged; Brain research; Cardiovascular disease; Carotid arteries; Carotid Artery, Internal - diagnostic imaging; Carotid Artery, Internal - surgery; Carotid stenosis; Carotid Stenosis - diagnostic imaging; Carotid Stenosis - surgery; Coronary vessels; Diabetes; Diffusion; Diffusion Magnetic Resonance Imaging - methods; Diffusion-weighted imaging; Endarterectomy; Endarterectomy, Carotid - methods; Female; Humans; Hypertension; Ischemia; Male; Medical imaging; Middle Aged; Neurology; Neurosurgery; NMR; Nuclear magnetic resonance; Radiography; Risk factors; Stroke; Studies; White Matter - pathology; White matter hyperintensities; Carotid stenosis; Diffusion-weighted imaging; White matter hyperintensities; Ischemia; Endarterectomy
• ISSN: 0303-8467; 1872-6968
• DOI: 10.1016/j.clineuro.2015.03.002

Highlights • Carotid stenosis is associated with hemodynamic cerebral ischemia. • DWI allows for the detection of tissue changes beyond areas of apparent signal abnormality. • Carotid stenosis is associated with increased diffusion, partially reversible by endarterectomy. • White matter lesions are more extensive in the ipsilateral hemisphere of carotid stenosis. • Carotid stenosis may induce chronic low-grade ischemic damage to cerebral parenchyma.