Platelet phagocytosis by leukocytes in a patient with cerebral hemorrhage and thrombocytopenia caused by gram-negative bacterial infection

• Published in: Journal of international medical research Vol. 50; no. 2; p. 3000605221079102
• Main Authors: Wu, Xiuji, Li, Youjun, Yang, Xiaoyang
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.02.2022; Sage Publications Ltd; SAGE Publishing
• Subjects: Bacteria; Bacterial infections; Blood Platelets; Case Reports; Cerebral Hemorrhage - complications; Cerebral Hemorrhage - diagnostic imaging; Gram-Negative Bacterial Infections - complications; Hemorrhage; Humans; Infections; Leukocytes; Phagocytosis; Thrombocytopenia; Thrombocytopenia - etiology; phagocytosis; thrombocytopenia; leukocyte; case report; Cerebral haemorrhage; bacterial infection; neutrophil
• ISSN: 0300-0605; 1473-2300
• DOI: 10.1177/03000605221079102

Bacteria-induced thrombocytopenia is a common clinical disease that is often ignored by clinical and scientific research. Thus, exploring the mechanism and principle of bacteria-induced thrombocytopenia could facilitate the development of new diagnostic, preventative, and treatment modalities for thrombocytopenia. This case report describes a case of platelet phagocytosis by neutrophils and monocytes in a patient with cerebral hemorrhage and thrombocytopenia caused by gram-negative bacterial infection. After the infection was eradicated, platelet phagocytosis was alleviated, and his platelet count normalized. Cellular immunity may be an important cause of bacteria-induced thrombocytopenia in patients with cerebral hemorrhage.