Technical Note: Therapeutic Cessation of Lactation of Staphylococcus aureus-Infected Mammary Quarters

• Published in: Journal of dairy science Vol. 84; no. 9; pp. 1976 - 1978
• Main Authors: Middleton, J.R., Fox, L.K.
• Format: Journal Article
• Language: English
• Published: Savoy, IL Elsevier Inc 01.09.2001; Am Dairy Sci Assoc; American Dairy Science Association
• Subjects: Animal bacterial diseases; Animal productions; Animals; Anti-Infective Agents, Local - pharmacology; Bacterial diseases; Biological and medical sciences; Cattle - physiology; Chlorhexidine - pharmacology; Female; Fundamental and applied biological sciences. Psychology; Infectious diseases; Lactation - drug effects; Mammary Glands, Animal - drug effects; Mammary Glands, Animal - microbiology; mastitis; Mastitis, Bovine - drug therapy; Mastitis, Bovine - microbiology; Medical sciences; Povidone-Iodine - pharmacology; Staphylococcal Infections - drug therapy; Staphylococcal Infections - veterinary; Staphylococcus aureus; Staphylococcus aureus - drug effects; Terrestrial animal productions; therapy; Vertebrates; MWD; mastitis; therapy; Staphylococcus aureus; Mastitis; Farming animal; Lactation; Ruminant animal; Cure; Dairy cattle; Non target effect; Experimental study; Veterinary medicine; Milk production; Povidone; Mammary gland diseases; Vertebrata; Chemotherapy; Mammalia; Pathogenic; Bacteria; Micrococcales; Micrococcaceae; Chlorhexidine; Artiodactyla; Ungulata; Iodine
• ISSN: 0022-0302; 1525-3198
• DOI: 10.3168/jds.S0022-0302(01)74640-1

The objective of the present study was to compare the ability of chlorhexidine and povidone-iodine to cause cessation of lactation in Staphylococcus aureus-infected mammary quarters, assess milk production in the treated quarter in the subsequent lactation, and evaluate whether microbiological cure was obtained. Fourteen mid- to late-lactation Holstein-Friesian dairy cattle from the Washington State University dairy herd with single mammary quarter S. aureus intramammary infections were studied. Cows were randomly assigned to one of two treatment groups, povidone-iodine or chlorhexidine. Cows in the povidone-iodine group were infused with 120ml of 5% povidone-iodine solution (0.5% iodine) after complete milk-out. Chlorhexidine-treated cows were infused with a proprietary chlorhexidine suspension after two milkings 24h apart. Treated mammary quarters were not milked for the rest of the lactation. Milk production from each mammary quarter (kg of milk/quarter) was measured using in-line volume flow meters for 5 consecutive days before treatment and again at the start of the subsequent lactation. Povidone-iodine caused permanent cessation of lactation in the treated quarter, whereas 71% of the chlorhexidine-treated mammary quarters returned to function in the subsequent lactation. Hence, if the primary objective is to eliminate the mammary quarter from lactation, and thereby presumably lower the risk of herdmates acquiring new S. aureus intramammary infection, then povidone-iodine appears to be the best of the two methods. No difference in total milk production between lactation one and two in either group was found, suggesting that permanent loss of a quarter was not detrimental to overall milk production.