A Case of M-Type Phospholipase A2 Receptor-Associated Membranous Nephropathy With IgG4-Positive Cells Infiltration in the Interstitium

A 70-year-old man was referred to our department for evaluation of nephrotic syndrome. Renal biopsy revealed membranous nephropathy (MN). Immunohistochemical analysis demonstrated IgG4-positive staining in the glomeruli and interstitial cells. The presence of serum anti-phospholipase A2 receptor (PL...

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Published inClinical medicine insights. Case reports Vol. 15; p. 11795476221078635
Main Authors Ishibuchi, Kento, Iwakura, Takamasa, Ema, Chiemi, Nakagami, Daisuke, Uchiyama, Yuri, Kaneko, Mai, Fukasawa, Hirotaka, Matsuyama, Takashi, Yasuda, Hideo, Furuya, Ryuichi
Format Journal Article
LanguageEnglish
Published London, England SAGE Publications 01.02.2022
Sage Publications Ltd
SAGE Publishing
Subjects
Case Report
Case reports
Immunoglobulins
Immunohistochemistry
Kidney diseases
IgG4-RKD
M-type phospholipase A2 receptor
membranous nephropathy
PLA2R
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Summary:A 70-year-old man was referred to our department for evaluation of nephrotic syndrome. Renal biopsy revealed membranous nephropathy (MN). Immunohistochemical analysis demonstrated IgG4-positive staining in the glomeruli and interstitial cells. The presence of serum anti-phospholipase A2 receptor (PLA2R) antibody and enhanced staining of PLA2R in the glomeruli was noted. Computed tomography unidentified the extrarenal lesions of IgG4-related disease. He was diagnosed with PLA2R-associated MN possibly complicated with IgG4 related kidney disease (IgG4-RKD). Storiform fibrosis, a typical manifestation of IgG4-RKD, was not apparent. We herein describe a case of serologically and histologically confirmed PLA2R-associated MN with IgG4+ cell infiltration into the interstitium without any signs of IgG4-RD.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
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ObjectType-Report-1
These authors contributed equally to this study as co-first authors.
ISSN:1179-5476
1179-5476
DOI:10.1177/11795476221078635