First-phase insulin release in normal children
Normal values for the first-phase insulin release during an intravenous glucosetolerance test are not yet well defined for children and adolescents. In this study, 69 normal subjects (aged 7 to 22 years) who had no family history of type I diabetes, a normal glycohemoglobin value, and a negative isl...
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Published in | The Journal of pediatrics Vol. 123; no. 5; pp. 733 - 738 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
New York, NY
Mosby, Inc
01.11.1993
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | Normal values for the first-phase insulin release during an intravenous glucosetolerance test are not yet well defined for children and adolescents. In this study, 69 normal subjects (aged 7 to 22 years) who had no family history of type I diabetes, a normal glycohemoglobin value, and a negative islet cell antibody test result underwent a standard intravenous glucose tolerance test. The mean (±SEM) first-phase insulin release increased with age and pubertal status: 7 to 10 years, 93±10.1 mIU/L; 11 to 15 years, 172.7±22.3 mIU/L; and 16 to 22 years, 163±28.5 mIU/L. The mean intraindividual variability in 11 subjects who underwent a second test was 23.6%. Acute stress, as estimated by observer assessment or by blood catecholamine levels, did not significantly correlate with firstphase insulin release. We conclude that first-phase insulin release is markedly lower in prepubertal children than in adolescents and young adults. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0022-3476 1097-6833 |
DOI: | 10.1016/S0022-3476(05)80847-9 |