A novel home-based method for preparing suspensions of anti-TB drugs

BACKGROUND: Tablets are the most widely available dosage form for the treatment of TB; however, adult tablets fail to meet the needs of young children who cannot swallow these tablets or require dose titration. We tested a new, simple device (XTEMP-R®) and the methodology for converting tablets of T...

Full description

Saved in:
Bibliographic Details
Published inThe international journal of tuberculosis and lung disease Vol. 27; no. 11; pp. 810 - 815
Main Authors Taneja, R., Nahata, M. C., Scarim, J., Pande, P. G., Scarim, A., Hoddinott, G., Fourie, C. L., Jew, R. K., Schaaf, H. S., Hesseling, A. C., Garcia-Prats, A. J., Inabathina, K. Rao
Format Journal Article
LanguageEnglish
Published Paris International Union Against Tuberculosis and Lung Disease 01.11.2023
International Union against Tuberculosis and Lung Disease (IUATLD)
Subjects
Age-Appropriate Dosing
Antibiotics
Caregivers
Children
Clofazimine
Dosage
Dosing Device
Drug dosages
Drugs
Dysphagia
Original
Pediatric
Pediatrics
Tablets
Titration
Xtemp-R
Online AccessGet full text

Cover

More Information
Summary:BACKGROUND: Tablets are the most widely available dosage form for the treatment of TB; however, adult tablets fail to meet the needs of young children who cannot swallow these tablets or require dose titration. We tested a new, simple device (XTEMP-R®) and the methodology for converting tablets of TB drugs into a homogeneous suspension for home use by children and caregivers.METHODS: XTEMP-R is a new device used for converting tablets into liquid preparations. Four TB drugs – pretomanid, delamanid, clofazimine and bedaquiline – were dispersed in the device utilizing water and simple syrup. The reproducibility of accurately delivering aliquots from the suspension upon preparation and upon redispersion after storing for 2 days was studied.RESULTS: Suspensions of each of the drugs tested were easily prepared in about 10 min and were visually uniform in consistency. Dosages in 2 and 5 mL were assessed in suspension, and those in 5 mL tested upon redispersion after 2 days. The observed range for these dosages spanned from 94.6% to 101.1% of the theoretical concentration for the suspensions under examination. The cleaned device had no detectable residual drug.CONCLUSION: XTEMP-R can be used at home by caregivers to prepare doses of suspensions accurately for children and patients who cannot swallow tablets.
Bibliography:1027-3719(20231101)27:11L.810;1-
(R) Medicine - General
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Previous articles in the series. Editorial: Alffenaar JWC, Marais BJ, Touw DJ. Paediatric formulations for the treatment of drug resistant TB: closing the gaps. Int J Tuberc Lung Dis 2022;26(12):1097–1100. Articles: No 1: Taneja R, et al. Stable sugar and sugar-free suspensions of pretomanid for treatment of TB in children. Int J Tuberc Lung Dis 2022;26(12):1112–1117. No 2: Taneja R, et al. Sugar and sugar-free liquid formulations of delamanid for patients with rifampicin-resistant TB. Int J Tuberc Lung Dis 2023;27(1):13–18. No 3: Taneja R, et al. Extemporaneously compounded liquid formulations of clofazimine. Int J Tuberc Lung Dis 2023;27(2):106–112. No 4: Taneja R, et al. Stable, compounded bedaquiline suspensions to support practical implementation of pediatric dosing in the field. Int J Tuberc Lung Dis 2023;27(3):189–194. Editorial: Viljoen A, et al. Community perspective on child-friendly medications for drug-resistant TB: importance, priorities and advocacy. Int J Tuberc Lung Dis 2023;27(9):655–657.
ISSN:1027-3719
1815-7920
DOI:10.5588/ijtld.23.0165