Translocation of zinc may contribute to seizure-induced death of neurons

Rats were subjected to seizures induced by kainic acid, and the resulting changes in CNS zinc staining were studied with the toluene sulfonamide quinoline fluorescence method. Seizures caused a loss of zinc staining from presynaptic boutons in many limbic and cerebrocortical regions. Simultaneously,...

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Bibliographic Details
Published inBrain research Vol. 480; no. 1-2; p. 317
Main Authors Frederickson, C J, Hernandez, M D, McGinty, J F
Format Journal Article
LanguageEnglish
Published Netherlands 20.02.1989
Subjects
Amygdala - drug effects
Amygdala - metabolism
Amygdala - physiopathology
Animals
Cell Survival
Cerebellum - metabolism
Hippocampus - drug effects
Hippocampus - metabolism
Hippocampus - physiopathology
In Vitro Techniques
Kainic Acid
Nerve Degeneration
Quinolines
Rats
Seizures - chemically induced
Seizures - metabolism
Seizures - physiopathology
Sulfonamides
Toluene
Zinc - metabolism
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Summary:Rats were subjected to seizures induced by kainic acid, and the resulting changes in CNS zinc staining were studied with the toluene sulfonamide quinoline fluorescence method. Seizures caused a loss of zinc staining from presynaptic boutons in many limbic and cerebrocortical regions. Simultaneously, the postsynaptic neurons that were degenerating (acidophilic) in those regions as a result of the seizure developed intense fluorescence for zinc. A possible role for zinc in the death of the postsynaptic neurons is suggested.
ISSN:0006-8993
DOI:10.1016/0006-8993(89)90199-6