Experience with Novalis stereotactic radiosurgery for vestibular schwannomas

• Published in: Clinical neurology and neurosurgery Vol. 121; pp. 30 - 34
• Main Authors: Lo, Wei-Lun, Yang, Ka-Yen, Huang, Yu-Jie, Chen, Wu-Fu, Liao, Chen-Chieh, Huang, Yu-Hua
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.06.2014; Elsevier Limited
• Subjects: Adult; Age; Aged; Aged, 80 and over; Ataxia; Cranial nerve; Cranial Nerves - pathology; Female; Follow-Up Studies; Headaches; Hearing loss; Hospitals; Humans; Male; Medical imaging; Medical treatment; Middle Aged; Neurofibromatosis 2 - surgery; Neurology; Neuroma, Acoustic - surgery; Neurosurgery; Novalis; Outcome; Radiosurgery; Retrospective Studies; Stereotactic radiosurgery; Treatment Outcome; Tumors; Vertigo; Vestibular schwannoma; Cranial nerve; Stereotactic radiosurgery; Novalis; Outcome; Vestibular schwannoma
• ISSN: 0303-8467; 1872-6968
• DOI: 10.1016/j.clineuro.2014.03.012

Abstract Background The Novalis linear accelerator system, a well developed modality, can be used for stereotactic radiosurgery (SRS). The aim of this study was to clarify the efficiency and safety of Novalis SRS in treating vestibular schwannomas. Materials and methods This 4-year retrospective study enrolled 23 patients with 26 vestibular schwannomas (3 patients suffered from neurofibromatosis Type II). Five patients had undergone tumor resection. All 26 tumors were treated using Novalis SRS, with a prescription dose that varied between 10 and 16 Gy (mean, 11.8 ± 1.7 Gy). The average follow-up period was 56.5 ± 22.1 months (range, 17–87 months). Results There were 9 men and 14 women. Their mean age at the time of treatment was 54.0 ± 14.6 years (range, 27–84 years). On average, the original size of the tumor was 19.0 ± 7.2 mm in maximal diameter (range, 4.6–39.9 mm). At the last follow-up, 20 tumors had regressed (76.9%), and there was no observed change in the size of 3 tumors (11.5%). Three of 26 tumors (11.5%) enlarged more than 2 mm in one direction. Thus the ultimate radiological tumor control rate was 88.5% (23/26). In addition, 20 (87.0%) patients retained their pre-irradiation hearing function. Facial and trigeminal nerve function were both preserved in all patients. No death occurred during the follow-up, and no patient was treated with a second SRS or converted to tumor resection. Conclusion Novalis SRS is a reliable treatment option for vestibular schwannomas. With an optimal radiation dose, satisfactory tumor control can be achieved while preserving cranial nerve function.