Single-cell transcriptomics reveals specific RNA editing signatures in the human brain

While RNA editing by A-to-I deamination is a requisite for neuronal function in humans, it is under-investigated in single cells. Here we fill this gap by analyzing RNA editing profiles of single cells from the brain cortex of living human subjects. We show that RNA editing levels per cell are bimod...

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Bibliographic Details
Published inRNA (Cambridge) Vol. 23; no. 6; pp. 860 - 865
Main Authors Picardi, Ernesto, Horner, David S., Pesole, Graziano
Format Journal Article
LanguageEnglish
Published United States Cold Spring Harbor Laboratory Press 01.06.2017
Subjects
Astrocytes - metabolism
Brain - metabolism
Cluster Analysis
Databases, Nucleic Acid
Deamination
Editing
Gene Expression Profiling
Gene Expression Regulation
Humans
Neurons - metabolism
RNA Editing
Single-Cell Analysis - methods
Transcriptome
RNA editing
single cell
RNA-seq
transcriptome
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Summary:While RNA editing by A-to-I deamination is a requisite for neuronal function in humans, it is under-investigated in single cells. Here we fill this gap by analyzing RNA editing profiles of single cells from the brain cortex of living human subjects. We show that RNA editing levels per cell are bimodally distributed and distinguish between major brain cell types, thus providing new insights into neuronal dynamics.
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ISSN:1355-8382
1469-9001
1469-9001
DOI:10.1261/rna.058271.116