Ellagitannin, Phenols, and Flavonoids as Antibacterials from Acalypha arvensis (Euphorbiaceae)

• Published in: Plants (Basel) Vol. 11; no. 3; p. 300
• Main Authors: Ble-González, Ever A, Gómez-Rivera, Abraham, Zamilpa, Alejandro, López-Rodríguez, Ricardo, Lobato-García, Carlos Ernesto, Álvarez-Fitz, Patricia, Gutierrez-Roman, Ana Silvia, Perez-García, Ma Dolores, Bugarin, Alejandro, González-Cortazar, Manasés
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 24.01.2022; MDPI
• Subjects: Acalypha arvensis; Acetic acid; Acids; antibacterial; Antibacterial activity; Antibacterial agents; Antibiotics; Antimicrobial agents; Bacteria; Bacterial infections; Caffeic acid; Chlorogenic acid; Chromatography; corilagin; Drug resistance; ellagitannin; Ethanol; Ethyl acetate; Euphorbiaceae; Flavonoids; Fractionation; Gram-positive bacteria; Hexanes; Infectious diseases; Klebsiella; Medicinal plants; Metabolites; Methicillin; Microorganisms; n-Hexane; Natural products; Phenols; Pneumonia; Pseudomonas aeruginosa; Quercetin; Retention; Rutin; Salmonella; Spectrum analysis; Staphylococcus aureus; Staphylococcus infections; Strains (organisms); Streptococcus infections; corilagin; antibacterial; Acalypha arvensis; flavonoids; Staphylococcus aureus; ellagitannin
• ISSN: 2223-7747; 2223-7747
• DOI: 10.3390/plants11030300

There is a significant need to gain access to new and better antibacterial agents. a plant from the Euphorbiaceae family, has been used in traditional medicine for centuries to treat infectious diseases. This manuscript reports the isolation, characterization, and antibacterial screening of 8 natural products extracted from maceration of aerial parts of Specifically, three extracts were assessed ( -hexane, ethyl acetate, and ethanol), in which antibacterial activity was evaluated against diverse bacterial strains. The ethanolic extract showed the best activity against methicillin-sensitive and methicillin-resistant , and strains, which supports the medicinal properties attributed to this plant. The chromatographic fractions AaR4 and AaR5 were the most bioactive, in which the ellagitannin natural product known as corilagin ( ) was identified for the first time in this plant. Therefore, it can be said that this is the main chemical responsible for the observed antibacterial activity. However, we also identified chlorogenic acid ( ), rutin ( ), quercetin-3- -glucoside ( ), caffeic acid ( ), among others ( - ). Hence, this plant can be considered to be a good alternative to treat health-related issues caused by various bacteria.