Effect of oral l-arginine on oxidant stress, endothelial dysfunction, and systemic arterial pressure in young cardiac transplant recipients

• Published in: The American journal of cardiology Vol. 94; no. 6; pp. 828 - 831
• Main Authors: Lim, D.Scott, Mooradian, Stephen J., Goldberg, Caren S., Gomez, Carlen, Crowley, Dennis C., Rocchini, Albert P., Charpie, John R.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 15.09.2004; Elsevier; Elsevier Limited
• Subjects: Administration, Oral; Adolescent; Adult; Arginine - administration & dosage; Arginine - pharmacology; Biological and medical sciences; Blood pressure; Cardiology; Cardiology. Vascular system; Child; Children & youth; Coronary Vessels - drug effects; Drug therapy; Endothelium, Vascular - drug effects; Endothelium, Vascular - pathology; Female; Heart; Heart Transplantation; Humans; Hypertension; Hypertension - drug therapy; Hypertension - etiology; Male; Medical sciences; Oxidative Stress; Stress; Transplants & implants; Young adults; Heart; Transplantation; Systemic; Oxidant; Homotransplantation; Stress; Oral cavity; Treatment; Arginine; Dysfunction; Surgery; Graft; Arterial pressure; Disseminated
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/j.amjcard.2004.05.073

Oral l-arginine therapy reverses endothelial dysfunction and attenuates high blood pressure in hypertensive cardiac transplant recipients. l-arginine corrects derangements in the vascular endothelial nitric oxide (NO)-dependent signaling pathway. Our data support the concept that cardiac transplant recipients use excess endogenous NO from l-arginine supplementation to buffer increased vascular oxidant stress.