Clinical commentary: Medical ethics and the ramifications of equipoise in clinical research. Is a confirmatory trial using a non-bevacizumab containing arm feasible in patients with recurrent cervical cancer?

Highlights • This clinical commentary addresses the topic of medical ethics in clinical research. • Describes the ethical principle of ‘clinical equipoise’ as it relates to clinical trials in gynecologic oncology • Can clinical equipoise exist in harmony with medical ethics and promote progress in c...

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Published inGynecologic oncology Vol. 134; no. 3; pp. 447 - 449
Main Authors Krill, Lauren S, Adelson, Joel W, Randall, Leslie M, Bristow, Robert E
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.09.2014
Subjects
Angiogenesis Inhibitors - therapeutic use
Antibodies, Monoclonal, Humanized - therapeutic use
Bevacizumab
Bioethical Issues
Biomedical Research - ethics
Clinical Trials as Topic - ethics
Ethics, Medical
Female
Hematology, Oncology and Palliative Medicine
Humans
Neoplasm Recurrence, Local - drug therapy
Obstetrics and Gynecology
Testosterone - analogs & derivatives
Testosterone - therapeutic use
Uterine Cervical Neoplasms - drug therapy
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Summary:Highlights • This clinical commentary addresses the topic of medical ethics in clinical research. • Describes the ethical principle of ‘clinical equipoise’ as it relates to clinical trials in gynecologic oncology • Can clinical equipoise exist in harmony with medical ethics and promote progress in cancer research simultaneously?
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0090-8258
1095-6859
DOI:10.1016/j.ygyno.2014.06.017