Enhanced Replication of Highly Pathogenic Influenza A(H7N9) Virus in Humans

To clarify the threat posed by emergence of highly pathogenic influenza A(H7N9) virus infection among humans, we characterized the viral polymerase complex. Polymerase basic 2-482R, polymerase basic 2-588V, and polymerase acidic-497R individually or additively enhanced virus polymerase activity, ind...

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Published inEmerging infectious diseases Vol. 24; no. 4; pp. 746 - 750
Main Authors Yamayoshi, Seiya, Kiso, Maki, Yasuhara, Atsuhiro, Ito, Mutsumi, Shu, Yuelong, Kawaoka, Yoshihiro
Format Journal Article
LanguageEnglish
Published United States U.S. National Center for Infectious Diseases 01.04.2018
Centers for Disease Control and Prevention
Subjects
Amino Acid Substitution
Amino acids
Animals
Dispatch
enhanced polymerase activity
Genes, Viral
H7N9
Health aspects
Highly pathogenic
Humans
Influenza
Influenza A Virus, H7N9 Subtype - physiology
Influenza, Human - epidemiology
Influenza, Human - virology
Lectins
Mice
Mutation
Orthomyxoviridae Infections - virology
PB2
Virulence - genetics
Virus Replication
influenza
PA
PB2
viruses
Highly pathogenic
enhanced polymerase activity
H7N9
respiratory infections
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Summary:To clarify the threat posed by emergence of highly pathogenic influenza A(H7N9) virus infection among humans, we characterized the viral polymerase complex. Polymerase basic 2-482R, polymerase basic 2-588V, and polymerase acidic-497R individually or additively enhanced virus polymerase activity, indicating that multiple replication-enhancing mutations in 1 isolate may contribute to virulence.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1080-6040
1080-6059
1080-6059
DOI:10.3201/eid2404.171509