Targeted Metabolomics to Assess Exposure to Environmental Chemicals of Concern in Japanese Quail at Two Life Stages

This proof-of-concept study characterizes the Japanese quail ( ) hepatic metabolome following exposure to benzo[a]pyrene, chlorpyrifos, ethinylestradiol, fluoxetine hydrochloride, hexabromocyclododecane, lead(II)nitrate, seleno-L-methionine, and trenbolone in embryos and adults. The analysis reveale...

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Published inMetabolites Vol. 11; no. 12; p. 850
Main Authors Legrand, Elena, Basu, Niladri, Hecker, Markus, Crump, Doug, Xia, Jianguo, Chandramouli, Bharat, Butler, Heather, Head, Jessica A
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 08.12.2021
MDPI
Subjects
avian
Benzo(a)pyrene
Biomarkers
Chemicals
Chlorpyrifos
Communication
Coturnix japonica
early life stage
Embryos
environmental metabolomics
Ethinylestradiol
Flame retardants
Fluoxetine
LC-MS
Lipid metabolism
Lipids
Liver
mass spectrometry
Metabolism
Metabolites
Metabolomics
Methionine
NMR
Nuclear magnetic resonance
Oxidative stress
Steroids
Trenbolone
mass spectrometry
LC-MS
environmental metabolomics
avian
early life stage
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Abstract This proof-of-concept study characterizes the Japanese quail ( ) hepatic metabolome following exposure to benzo[a]pyrene, chlorpyrifos, ethinylestradiol, fluoxetine hydrochloride, hexabromocyclododecane, lead(II)nitrate, seleno-L-methionine, and trenbolone in embryos and adults. The analysis revealed effects on lipid metabolism following exposure to several chemicals at both life stages. The most pronounced effects were observed in embryos exposed to 41.1 μg/g chlorpyrifos. This work highlighted challenges and the need for further avian metabolomics studies.
AbstractList This proof-of-concept study characterizes the Japanese quail ( Coturnix japonica ) hepatic metabolome following exposure to benzo[a]pyrene, chlorpyrifos, ethinylestradiol, fluoxetine hydrochloride, hexabromocyclododecane, lead(II)nitrate, seleno-L-methionine, and trenbolone in embryos and adults. The analysis revealed effects on lipid metabolism following exposure to several chemicals at both life stages. The most pronounced effects were observed in embryos exposed to 41.1 μg/g chlorpyrifos. This work highlighted challenges and the need for further avian metabolomics studies.
This proof-of-concept study characterizes the Japanese quail (Coturnix japonica) hepatic metabolome following exposure to benzo[a]pyrene, chlorpyrifos, ethinylestradiol, fluoxetine hydrochloride, hexabromocyclododecane, lead(II)nitrate, seleno-L-methionine, and trenbolone in embryos and adults. The analysis revealed effects on lipid metabolism following exposure to several chemicals at both life stages. The most pronounced effects were observed in embryos exposed to 41.1 μg/g chlorpyrifos. This work highlighted challenges and the need for further avian metabolomics studies.
This proof-of-concept study characterizes the Japanese quail ( ) hepatic metabolome following exposure to benzo[a]pyrene, chlorpyrifos, ethinylestradiol, fluoxetine hydrochloride, hexabromocyclododecane, lead(II)nitrate, seleno-L-methionine, and trenbolone in embryos and adults. The analysis revealed effects on lipid metabolism following exposure to several chemicals at both life stages. The most pronounced effects were observed in embryos exposed to 41.1 μg/g chlorpyrifos. This work highlighted challenges and the need for further avian metabolomics studies.
Author Crump, Doug
Head, Jessica A
Butler, Heather
Basu, Niladri
Hecker, Markus
Chandramouli, Bharat
Legrand, Elena
Xia, Jianguo
AuthorAffiliation 1 Faculty of Agricultural and Environmental Sciences, McGill University, Montréal, QC H9X 3V9, Canada; niladri.basu@mcgill.ca (N.B.); jeff.xia@mcgill.ca (J.X.); jessica.head@mcgill.ca (J.A.H.)
4 SGS-AXYS Analytical Services Ltd., 2045 Mills Road West, Sidney, BC V8L 5X2, Canada; Bharat.Chandramouli@sgs.com (B.C.); hjbutler@blackbeckresearch.com (H.B.)
2 Toxicology Centre and School of the Environment and Sustainability, University of Saskatchewan, Saskatoon, SK S7N 5B3, Canada; markus.hecker@usask.ca
3 Environment and Climate Change Canada, National Wildlife Research Centre, Carleton University, Ottawa, ON K1S 5B6, Canada; doug.crump@ec.gc.ca
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– name: 1 Faculty of Agricultural and Environmental Sciences, McGill University, Montréal, QC H9X 3V9, Canada; niladri.basu@mcgill.ca (N.B.); jeff.xia@mcgill.ca (J.X.); jessica.head@mcgill.ca (J.A.H.)
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CitedBy_id crossref_primary_10_1002_etc_5464
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Keywords mass spectrometry
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  doi: 10.1007/s11356-019-05075-4
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Snippet This proof-of-concept study characterizes the Japanese quail ( ) hepatic metabolome following exposure to benzo[a]pyrene, chlorpyrifos, ethinylestradiol,...
This proof-of-concept study characterizes the Japanese quail (Coturnix japonica) hepatic metabolome following exposure to benzo[a]pyrene, chlorpyrifos,...
This proof-of-concept study characterizes the Japanese quail ( Coturnix japonica ) hepatic metabolome following exposure to benzo[a]pyrene, chlorpyrifos,...
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SubjectTerms avian
Benzo(a)pyrene
Biomarkers
Chemicals
Chlorpyrifos
Communication
Coturnix japonica
early life stage
Embryos
environmental metabolomics
Ethinylestradiol
Flame retardants
Fluoxetine
LC-MS
Lipid metabolism
Lipids
Liver
mass spectrometry
Metabolism
Metabolites
Metabolomics
Methionine
NMR
Nuclear magnetic resonance
Oxidative stress
Steroids
Trenbolone
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Title Targeted Metabolomics to Assess Exposure to Environmental Chemicals of Concern in Japanese Quail at Two Life Stages
URI https://www.ncbi.nlm.nih.gov/pubmed/34940609
https://www.proquest.com/docview/2612812201
https://pubmed.ncbi.nlm.nih.gov/PMC8715744
https://doaj.org/article/32b916d1db044f91a74d5491951e7c3a
Volume 11
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