Targeted Metabolomics to Assess Exposure to Environmental Chemicals of Concern in Japanese Quail at Two Life Stages

This proof-of-concept study characterizes the Japanese quail ( ) hepatic metabolome following exposure to benzo[a]pyrene, chlorpyrifos, ethinylestradiol, fluoxetine hydrochloride, hexabromocyclododecane, lead(II)nitrate, seleno-L-methionine, and trenbolone in embryos and adults. The analysis reveale...

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Bibliographic Details
Published inMetabolites Vol. 11; no. 12; p. 850
Main Authors Legrand, Elena, Basu, Niladri, Hecker, Markus, Crump, Doug, Xia, Jianguo, Chandramouli, Bharat, Butler, Heather, Head, Jessica A
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 08.12.2021
MDPI
Subjects
avian
Benzo(a)pyrene
Biomarkers
Chemicals
Chlorpyrifos
Communication
Coturnix japonica
early life stage
Embryos
environmental metabolomics
Ethinylestradiol
Flame retardants
Fluoxetine
LC-MS
Lipid metabolism
Lipids
Liver
mass spectrometry
Metabolism
Metabolites
Metabolomics
Methionine
NMR
Nuclear magnetic resonance
Oxidative stress
Steroids
Trenbolone
mass spectrometry
LC-MS
environmental metabolomics
avian
early life stage
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Summary:This proof-of-concept study characterizes the Japanese quail ( ) hepatic metabolome following exposure to benzo[a]pyrene, chlorpyrifos, ethinylestradiol, fluoxetine hydrochloride, hexabromocyclododecane, lead(II)nitrate, seleno-L-methionine, and trenbolone in embryos and adults. The analysis revealed effects on lipid metabolism following exposure to several chemicals at both life stages. The most pronounced effects were observed in embryos exposed to 41.1 μg/g chlorpyrifos. This work highlighted challenges and the need for further avian metabolomics studies.
ISSN:2218-1989
2218-1989
DOI:10.3390/metabo11120850