Epidermal growth factor levels are related to diastolic blood pressure and carotid artery stiffness

• Published in: Scandinavian cardiovascular journal : SCJ Vol. 41; no. 5; pp. 308 - 312
• Main Authors: Lundstam, Ulf, Hägg, Ulrika, Bergmann Sverrisdottir, Yrsa, Svensson, Lennart E. T., Gan, Li-ming
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 01.01.2007; Taylor & Francis
• Subjects: Adult; Blood Pressure - physiology; Carotid Artery Diseases - physiopathology; Carotid Artery, Common - pathology; CCA stiffness; Diastole; diastolic blood pressure; EGF; Epidermal Growth Factor - blood; Female; Humans; Male; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Middle Aged; Pilot Projects; Prospective Studies
• ISSN: 1401-7431; 1651-2006
• DOI: 10.1080/14017430701439508

Objectives. The epidermal growth factor (EGF) is believed to be involved in vascular remodelling. EGF receptors are expressed in human atherosclerotic tissue. Design. In order to study the role of EGF in vascular remodelling and early progression of atherosclerosis, 17 men and 16 women aged 20 to 45 years were recruited. Common Carotid Artery Stiffness index (CCA SI) and blood pressure were evaluated. In addition, serum levels of EGF and blood lipids were measured. Results. The levels of serum EGF were significantly correlated to diastolic blood pressure (p<0.05) and CCA SI (p<0.05). Subjects with EGF concentrations in the upper median had significantly lower levels of HDL (High Density Lipoproteins) (p<0.05) and ApoA1 (Apolipoprotein) (p<0.05) than those with EGF concentrations in the lower median. Discussion. High serum level of EGF is associated with elevated diastolic blood pressure and increased vessel stiffness suggesting a possible functional role of EGF in the cardiovascular system in a healthy population.