A study of dysphagia symptoms and esophageal body function in children undergoing anti-reflux surgery

• Published in: United European gastroenterology journal Vol. 6; no. 6; pp. 819 - 829
• Main Authors: Omari, T, Connor, F, McCall, L, Ferris, L, Ellison, S, Hanson, B, Abu-Assi, R, Khurana, S, Moore, D
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.07.2018
• Subjects: diagnosis; dysphagia; fundoplication; Gastroesophageal reflux; Original; Gastroesophageal reflux; dysphagia; diagnosis; fundoplication
• ISSN: 2050-6406; 2050-6414
• DOI: 10.1177/2050640618764936

Background The role of high-resolution esophageal impedance manometry (HRIM) for establishing risk for dysphagia after anti-reflux surgery is unclear. We conducted a prospective study of children with primary gastroesophageal reflux (GER) disease, for whom symptoms of dysphagia were determined pre-operatively and then post-operatively and we examined for features that may predict post-operative dysphagia. Methods Thirteen children (aged 6.8–15.5 years) undergoing work-up prior to 360o Nissen fundoplication were included in the study. A dysphagia score assessed symptoms at pre-operative study and post-operatively (mean 1.4 years). A HRIM procedure recorded 5-ml liquid, 5-ml viscous and 2-cm solid boluses. We assessed esophageal motility, esophago-gastric junction (EGJ) morphology, EGJ contractility and pressure-flow variables indicative of bolus distension pressures and bolus clearance pressures. A composite pressure-flow index score was also derived. Results Pre-operative pressure-flow index was positively correlated with post-operative dysphagia score (viscous bolus r = 0.771, p < 0.005). Of three variables that comprise the pressure-flow index, the ramp pressure measured during bolus clearance was the main driver of the effect seen (viscous bolus r = 0.819, p < 0.005). Conclusions In order to mitigate symptoms in relation to anti-reflux surgery, dysphagia symptoms and esophageal function need to be pre-operatively assessed. In patients with normal motility, an elevated pressure-flow index may predict post-operative dysphagia.