Structural studies of new macrolide antibiotics shurimycins A and B

The structures of new antibiotics, shurimycins A and B produced by Streptomyces hygroscopicus A1491, were elucidated from the physico-chemical properties, 2D NMR techniques and chemical degradation experiments to be 36-membered macrolides related to azalomycins, scopafungin and guanidylfungins. Shur...

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Bibliographic Details
Published inJournal of antibiotics Vol. 47; no. 6; pp. 688 - 696
Main Authors KUMAZAWA, S, ASAMI, Y, AWANE, K, OHTANI, H, FUKUCHI, C, MIKAWA, T, HAYASE, T
Format Journal Article
LanguageEnglish
Published Tokyo Japan Antibiotics Research Association 1994
Subjects
Anti-Bacterial Agents - biosynthesis
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Biological and medical sciences
Fermentation
Fungi - drug effects
General pharmacology
Gram-Positive Bacteria - drug effects
Hydrolysis
Macrolides
Magnetic Resonance Spectroscopy
Medical sciences
Molecular Conformation
Molecular Structure
Oxidation-Reduction
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Spectrometry, Mass, Fast Atom Bombardment
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
Streptomyces - metabolism
Streptomyces hygroscopicus
Streptomyces hygroscopicus
Streptomycetaceae
Molecular structure
Fermentation
Biological activity
Actinomycetales
Antibiotic
Antifungal agent
Microbial origin
Bacteria
Isolation
Actinomycetes
Physicochemical properties
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Summary:The structures of new antibiotics, shurimycins A and B produced by Streptomyces hygroscopicus A1491, were elucidated from the physico-chemical properties, 2D NMR techniques and chemical degradation experiments to be 36-membered macrolides related to azalomycins, scopafungin and guanidylfungins. Shurimycins were active against fungi and Gram-positive bacteria.
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ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.47.688