Skewed X Chromosome Inactivation and Female Preponderance in Autoimmune Thyroid Disease: An Association Study and Meta-Analysis

• Published in: The journal of clinical endocrinology and metabolism Vol. 99; no. 1; pp. E127 - E131
• Main Authors: Simmonds, Matthew J, Kavvoura, Fotini K, Brand, Oliver J, Newby, Paul R, Jackson, Laura E, Hargreaves, Chantal E, Franklyn, Jayne A, Gough, Stephen C. L
• Format: Journal Article
• Language: English
• Published: United States Endocrine Society 01.01.2014; Copyright by The Endocrine Society
• Subjects: Adult; Case-Control Studies; European Continental Ancestry Group - statistics & numerical data; Female; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Pedigree; Sex Factors; Thyroiditis, Autoimmune - epidemiology; Thyroiditis, Autoimmune - genetics; United Kingdom - epidemiology; X Chromosome Inactivation - genetics; Young Adult

Context: A number of small data sets have suggested a potential role for skewed X chromosome activation (XCI), away from the expected 50:50 parent of origin ratio, as an explanation for the strong female preponderance seen in the common autoimmune thyroid diseases (AITD), Graves' disease (GD),...