RUNX family: Regulation and diversification of roles through interacting proteins
The Runt‐related transcription factors (RUNX) belong to an ancient family of metazoan genes involved in developmental processes. Through multiple protein‐interacting partners, RUNX proteins have been implicated in diverse signaling pathways and cellular processes. The frequent inactivation of RUNX g...
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Published in | International journal of cancer Vol. 132; no. 6; pp. 1260 - 1271 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Hoboken
Wiley Subscription Services, Inc., A Wiley Company
15.03.2013
Wiley-Blackwell Wiley Subscription Services, Inc |
Subjects | |
Online Access | Get full text |
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Summary: | The Runt‐related transcription factors (RUNX) belong to an ancient family of metazoan genes involved in developmental processes. Through multiple protein‐interacting partners, RUNX proteins have been implicated in diverse signaling pathways and cellular processes. The frequent inactivation of RUNX genes in cancer indicates crucial roles for RUNX in tumor suppression. This review discusses the abilities of RUNX proteins, in particular RUNX3, to integrate oncogenic signals or environmental cues and to initiate appropriate tumor suppressive responses. |
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Bibliography: | Tel.: +65‐6516‐2242, Fax: +65‐6873‐9664 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
ISSN: | 0020-7136 1097-0215 |
DOI: | 10.1002/ijc.27964 |