RUNX family: Regulation and diversification of roles through interacting proteins

• Published in: International journal of cancer Vol. 132; no. 6; pp. 1260 - 1271
• Main Authors: Chuang, Linda Shyue Huey, Ito, Kosei, Ito, Yoshiaki
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 15.03.2013; Wiley-Blackwell; Wiley Subscription Services, Inc
• Subjects: Animals; Biological and medical sciences; Cancer; Cell Cycle; Core Binding Factor Alpha 2 Subunit - analysis; Core Binding Factor Alpha 2 Subunit - genetics; Core Binding Factor Alpha 2 Subunit - physiology; Core Binding Factor Alpha 3 Subunit - analysis; Core Binding Factor Alpha 3 Subunit - genetics; Core Binding Factor Alpha 3 Subunit - physiology; Core Binding Factor alpha Subunits - physiology; Humans; interacting proteins; Medical research; Medical sciences; Multiple tumors. Solid tumors. Tumors in childhood (general aspects); Mutation; Neoplasms - etiology; Oncology; post‐translational modification; Protein Processing, Post-Translational; Protein-Serine-Threonine Kinases - physiology; Proteins; RUNX; Signal Transduction - physiology; signaling pathways; Transcription, Genetic; Transforming Growth Factor beta - physiology; tumor suppressor; Tumor Suppressor Protein p53 - physiology; Tumors; Wnt Signaling Pathway - physiology; Human; tumor suppressor; Malignant tumor; RUNX; post-translational modification; Posttranslational modification; interacting proteins; Cancerology; signaling pathways; Signaling pathway; Genetics; Cancer; Tumor suppressor gene
• ISSN: 0020-7136; 1097-0215
• DOI: 10.1002/ijc.27964

The Runt‐related transcription factors (RUNX) belong to an ancient family of metazoan genes involved in developmental processes. Through multiple protein‐interacting partners, RUNX proteins have been implicated in diverse signaling pathways and cellular processes. The frequent inactivation of RUNX genes in cancer indicates crucial roles for RUNX in tumor suppression. This review discusses the abilities of RUNX proteins, in particular RUNX3, to integrate oncogenic signals or environmental cues and to initiate appropriate tumor suppressive responses.